1-Chloroethyl ethyl carbonate Chemical Properties

Melting point:

159-161°C

Boiling point:

159-161 °C(lit.)

Density 

1.136 g/mL at 20 °C(lit.)

refractive index 

n20/D 1.413

Flash point:

65°C

storage temp. 

2-8°C

solubility 

Chloroform

form 

Oil

color 

Colourless

BRN 

3536477

Stability:

Moisture Sensitive

InChIKey

YVRGKFXJZCTTRB-UHFFFAOYSA-N

CAS DataBase Reference

50893-36-2(CAS DataBase Reference)

EPA Substance Registry System

Carbonic acid, 1-chloroethyl ethyl ester (50893-36-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-28

WGK Germany 

3

F 

10-21

HS Code 

29209090

MSDS

• Language:English Provider:SigmaAldrich

1-Chloroethyl ethyl carbonate Usage And Synthesis

Chemical Properties

Clear pale yellowish liquid

Synthesis

71.5 g (0.5 mmol) of 1-chloroethyl chloroformate, 40 g of ethanol and 52.0 g of triethylamine were sequentially added to 250 mL of toluene solution under cooling at 0°C. After the addition was completed, the reaction system was kept stirred at 0°C for about 2 hours. Subsequently, the reaction system was slowly warmed to room temperature and the reaction was continued for 1 hour. Upon completion of the reaction, the solid impurities were removed by filtration and 78.5 g of the intermediate 1-chloroethyl ethyl carbonate (H-1) was purified by distillation.

References

[1] Synthesis, 1986, # 8, p. 627 - 632
[2] Patent: EP1437352, 2004, A1. Location in patent: Page 17
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 13, p. 5748 - 5763
[4] Patent: WO2016/207216, 2016, A1. Location in patent: Page/Page column 70
[5] Patent: CN107652239, 2018, A. Location in patent: Paragraph 0098

1-Chloroethyl ethyl carbonate(50893-36-2)Related Product Information

• Chloromethyl isopropyl carbonate
• Polycarbonate
• Ethyl acetate
• Ethyl chloroacetate
• Dimethyl carbonate
• Diethyl carbonate
• Vinylene carbonate
• Ethyl methyl carbonate
• Ethylene carbonate
• Lithium carbonate
• Propylene carbonate
• Diphenyl carbonate
• DIETHYLALUMINUM CHLORIDE
• Sodium carbonate
• Ethylparaben
• Phenethyl chloride
• Calcium carbonate
• Diethyl ethylmalonate