Fmoc-D-leucine Chemical Properties

Melting point:

155°C

Boiling point:

559.8±33.0 °C(Predicted)

Density 

1?+-.0.06 g/cm3(Predicted)

refractive index 

25 ° (C=1, DMF)

storage temp. 

2-8°C

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

pka

3.91±0.21(Predicted)

form 

powder to crystal

color 

White to Almost white

optical activity

Consistent with structure

Water Solubility 

Insoluble in water.

InChI

InChI=1S/C21H23NO4/c1-13(2)11-19(20(23)24)22-21(25)26-12-18-16-9-5-3-7-14(16)15-8-4-6-10-17(15)18/h3-10,13,18-19H,11-12H2,1-2H3,(H,22,25)(H,23,24)/t19-/m1/s1

InChIKey

CBPJQFCAFFNICX-LJQANCHMSA-N

SMILES

C(O)(=O)[C@@H](CC(C)C)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O

CAS DataBase Reference

114360-54-2(CAS DataBase Reference)

Safety Information

Safety Statements 

22-24/25

WGK Germany 

3

F 

10

HS Code 

29224999

MSDS

• Language:English Provider:SigmaAldrich

Fmoc-D-leucine Usage And Synthesis

Chemical Properties

White powder

Uses

A convergent synthesis of the proposed structure of (+)-pestalazine B has been achieved in 4 steps using the N-alkylation of an unprotected tryptophan diketopiperazine with a 3a-bromopyrrolidinoindoline where the condensation between L-tryptophan methyl ester and N-Fmoc-D-leucine in the presence of EDC as coupling agent afforded the corresponding L-Trp-D-Leu dipeptide.

Definition

ChEBI: Fmoc-D-Leu-OH is a leucine derivative.

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Fmoc-D-leucine(114360-54-2)Related Product Information

• L-tert-Leucine
• N-CARBOBENZOXY-DL-LEUCINE
• D-2-Amino-4-methylpentanoic acid
• Fmoc-Phe-OH
• L-Leucine
• Fmoc-Lys(Boc)-OH
• Nalpha-Fmoc-Ndelta-trityl-L-glutamine
• Fmoc-Asp(OtBu)-OH
• L-Fmoc-Aspartic acid alpha-tert-butyl ester
• 9-Fluorenylmethyl chloroformate
• 1-(4-BROMOPHENYL)CYCLOBUTANAMINE (HYDROCHLORIDE)
• Fmoc-OSu
• FMOC-D-CYCLOPROPYLALANINE
• FMOC-D-GLA(OTBU)2-OH
• FMOC-D-CHA-OH
• Fmoc
• Fmoc-N-methyl-D-leucine
• Fmoc-Leu-OH