FOLINIC ACID CALCIUM SALT PENTAHYDRATE Chemical Properties

Melting point:

240-250 °C

storage temp. 

0-6°C

solubility 

Aqueous (Slightly, Sonicated), Water (Sparingly, Heated, Sonicated)

form 

Solid

color 

Off-White to Pale Yellow

Stability:

Hygroscopic

Safety Information

Safety Statements 

24/25

MSDS

• Language:English Provider:ACROS

FOLINIC ACID CALCIUM SALT PENTAHYDRATE Usage And Synthesis

Uses

Anti-anemic (folate deficiency); antidote (to folic acid antagonists).

brand name

Wellcovorin (GlaxoSmithKline).

Clinical Use

Folinic acid rescue
Enhancement of 5-fluorouracil cytotoxicity in advanced colorectal cancer
Folate deficiency

Drug interactions

Potentially hazardous interactions with other drugs Should not be administered simultaneously with a folic acid antagonist as this may nullify the effect of the antagonist.
Cytotoxics: avoid with panitumumab and raltitrexed.

Metabolism

Folinic acid is a racemate where the L-form (L-5- formyl-tetrahydrofolate, L-5-formyl-THF), is the active enantiomer. The major metabolic product of folinic acid is 5-methyl-tetrahydrofolic acid (5-methyl-THF) which is predominantly produced in the liver and intestinal mucosa.
80-90% with the urine (5- and 10-formyltetrahydrofolates inactive metabolites), 5-8% with the faeces.

FOLINIC ACID CALCIUM SALT PENTAHYDRATE(41927-89-3)Related Product Information

• L-Tetrahydrofolic Acid
• Folinic acid
• Folinic acid, calcium salt pentahydrate, 95.0-105.0%
• N-(p-Aminobenzoyl)glutamic acid
• Pteridine, 5,6,7,8-tetrahydro- (6CI,7CI,8CI,9CI)
• 2,4-Diamino-6-hydroxypyrimidine
• BZ-GLU-OH
• Calcium folinate
• (S)-N-BENZYLGLUTAMIC ACID
• 6-HYDROXY-2,4,5-TRIAMINOPYRIMIDINE
• FOLINIC ACID CALCIUM SALT PENTAHYDRATE
• N-(4-Aminobenzoyl)-DL-glutamic acid
• 2,4,5-TRIAMINOPYRIMIDINE
• 5-Pyrimidinamine, N-methyl- (9CI)
• 6-AMINO-5-FORMYLAMINO-3H-PYRIMIDINE-4-ONE
• 2,4-Diamino-6-hydroxypyrimidine ,98%
• Calcium Folinate Pentahydrate