Phlorizin dihydrate Chemical Properties

Melting point:

113-114 °C(lit.)

alpha 

-52 º (c=3, EtOH)

storage temp. 

Inert atmosphere,2-8°C

solubility 

Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.

optical activity

[α]20/D 52°, c = 3 in ethanol

BRN 

66621

CAS DataBase Reference

7061-54-3(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

RTECS 

UC2080000

F 

3-10-23

Phlorizin dihydrate Usage And Synthesis

Uses

Phloridzin dihydrate has been used as:

• a Na^+-glucose cotransport inhibitor to test its effect in lowering blood glucose
• a hexose carrier inhibitor to prevent glucose derivative 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose (2-NBDG) uptake in sycamore cells
• a non-specific sodium-glucose co-transporter 2 (SGLT2) inhibitor in embryonic cardiomyocyte cell line H9C2 to investigate its protective effect on Dox-induced cytotoxicity

Biochem/physiol Actions

Phloridzin is a glycoside present in the leaves and bark of apple. It is also present in peel and pulp of the apple fruit. Phloridzin belongs to the dihydrochalcones class of compounds. Lactase catabolizes phloridzin to phloretin and glucose in small intestine epithelial cells. Phloridzin is an antidiabetic agent and is equally bioavailable as phloretin.

target

NO | PGE | NOS | COX

Phlorizin dihydrate(7061-54-3)Related Product Information

• Arbutin
• Wogonin
• ARTEMISININ
• AMYLOGLUCOSIDASE
• 2,5-DIDEOXY-2,5-IMINO-D-MANNITOL
• Rhamnosylvitexin
• Phloretin
• ALPHA-ACETYLPHENYLACETONITRILE
• alkyl polyglucoside
• Gluconic acid
• 4'-DEOXYPHLORIZIN
• Phloroglucinol
• 2-Bromopropiophenone
• DIETHYLPROPION
• Phlorizin
• Propiophenone
• FOROXYMITHINE
• Phlorizin dihydrate