Ethyl 4-aminophenylacetate Chemical Properties

Melting point:

48-50 °C

Boiling point:

120-122 °C(Press: 2 Torr)

Density 

1.112±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Methanol

form 

powder to crystal

pka

4.55±0.10(Predicted)

color 

White to Orange to Green

InChI

InChI=1S/C10H13NO2/c1-2-13-10(12)7-8-3-5-9(11)6-4-8/h3-6H,2,7,11H2,1H3

InChIKey

CFNDVXUTYPXOPG-UHFFFAOYSA-N

SMILES

C1(CC(OCC)=O)=CC=C(N)C=C1

CAS DataBase Reference

5438-70-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Safety Statements 

24/25

Hazard Note 

Irritant

HS Code 

29163400

MSDS

• Language:English Provider:ACROS
• Language:English Provider:ALFA

Ethyl 4-aminophenylacetate Usage And Synthesis

Chemical Properties

pinkish-white to beige powder

Uses

Used as an intermediate in pharmaceutical research.

Synthesis

A solution of (4-nitro-phenyl)-acetic acid ethyl ester (Preparation 266, 3.4 g, 16.1 mmol) in methanol (100 mL) was degassed with argon for 15 min, treated with 10% palladium on charcoal (700 mg), and then stirred at room temperature under hydrogen (balloon pressure) for 16 hours. The reaction mixture was filtered through celite, washed with methanol (2 × 20 mL) and the filtrate Ethyl 4-aminophenylacetate was evaporated in vacuo. Yield: 96%, 2.8 g, oil. 1H NMR (400 MHz, CDCl3) δ: 1.23 (t, 3H), 3.47 (s, 2H), 3.60 (br s, 2H), 4.11 (q, 2 H), 6.63 (d, 2H), 7.05 (d, 2H).

References

[1] Patent: EP3381898, 2018, A1. Location in patent: Paragraph 0200; 0272
[2] Patent: WO2015/161830, 2015, A1. Location in patent: Paragraph 00698
[3] Journal of the American Chemical Society, 2011, vol. 133, # 32, p. 12875 - 12879
[4] Chemical Communications, 2013, vol. 49, # 80, p. 9089 - 9091
[5] ChemCatChem, 2016, vol. 8, # 14, p. 2351 - 2355

Ethyl 4-aminophenylacetate(5438-70-0)Related Product Information

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