2,6-Dichloropyrazine Chemical Properties

Melting point:

55-58 °C (lit.)

Boiling point:

122 °C / 40mmHg

Density 

1.6445 (rough estimate)

refractive index 

1.6300 (estimate)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Soluble in ethanol and methanol.

form 

Crystals or Crystalline Powder

pka

-3.11±0.10(Predicted)

color 

White to beige

BRN 

2439

LogP

1.530

CAS DataBase Reference

4774-14-5(CAS DataBase Reference)

NIST Chemistry Reference

2,6-Dichloropyrazine(4774-14-5)

EPA Substance Registry System

2,6-Dichloropyrazine (4774-14-5)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-20/21/22

Safety Statements 

26-37/39-36/37/39-22-36

WGK Germany 

3

TSCA 

T

HazardClass 

IRRITANT

HS Code 

29339990

MSDS

• Language:English Provider:2,6-Dichloropyrazine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2,6-Dichloropyrazine Usage And Synthesis

Chemical Properties

White Powder

Uses

2,6-Dichloropyrazine is used in the preparation of pyrazine and pyridine compounds as ATR kinase inhibitors. It is also used in the synthesis of oxacalixarenes containing nitrogen heterocycles.

Synthesis

The production method of 2,6-dichloropyrazine comprises the following steps: carrying out ammoniation and cyclization reactions of raw materials comprising methyl chloroacetate, glyoxal and the like to prepare 2-hydroxypyrazine sodium, reacting 2-hydroxypyrazine sodium with phosphorous oxychloride under the catalysis action of N,N-dimethylaminopyridine to prepare 2-chloropyrazine, and chlorinating 2-chloropyrazine by chlorine under the catalysis action of triethylamine with dimethyl formamide as a solvent to prepare 2,6-dichloropyrazine.

2,6-Dichloropyrazine(4774-14-5)Related Product Information

• Glipizide
• Pyrazinamide
• Sulfachoropyrazine sodium
• 2,3-Dichloropyrazine,98%,2,3-DICHLOROPYRAZINE
• 2,5-DICHLOROPYRAZINE
• METHYL 3-AMINO-5,6-DICHLOROPYRAZINE-2-CARBOXYLATE,3-Amino-5,6-Dichloropyrazine-2-Carboxylic Acid Methyl Ester
• 2-AMINO-3,5-DICHLOROPYRAZINE
• 2-Dichloropyrazin
• 3,5-Dichloropyrazine-2-carboxylic acid
• Pyrazine
• 3,5-DICHLORO-2-ETHYLPYRAZINE
• METHYL 3,5-DICHLOROPYRAZINE-2-CARBOXYLATE
• 3,5-DICHLOROPYRAZINE-2-CARBOXAMIDE
• 2,6-DICHLORO-3-(TRIBUTYLSTANNYL)PYRAZINE
• 3,5,6-TRICHLORO-N-METHYLPYRAZIN-2-AMINE
• 3,5-Dichloropyrazine-2-carboxyamide
• 2,6-Dichloropyrazine
• 3,5-dichloropyrazine-2-carbaldehyde