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PHENYLGLYOXAL MONOHYDRATE

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PHENYLGLYOXAL MONOHYDRATE Basic information

Product Name:
PHENYLGLYOXAL MONOHYDRATE
Synonyms:
  • BENZOYLFORMALDEHYDE MONOHYDRATE
  • 2,2-DIHYDROXY-1-PHENYL-ETHANONE
  • PHENYLGLYOXAL
  • PHENYLGLYOXAL HYDRATE
  • PHENYLGLYOXAL MONOHYDRATE
  • P-PHENYLGLYOXAL MONOHYDRATE
  • 2,2-dihydroxy-1-phenyl-ethanon
  • 2,2-dihydroxy-acetophenon
CAS:
1075-06-5
MF:
C8H8O3
MW:
152.15
EINECS:
626-958-5
Mol File:
1075-06-5.mol
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PHENYLGLYOXAL MONOHYDRATE Chemical Properties

Melting point:
76-79 °C(lit.)
Boiling point:
142 °C125 mm Hg(lit.)
Density 
1.1603 (rough estimate)
refractive index 
1.5120 (estimate)
Flash point:
142°C/125mm
storage temp. 
Sealed in dry,Room Temperature
solubility 
95% ethanol: soluble5%, clear to very slightly hazy, colorless to light yellow
pka
10.97±0.41(Predicted)
form 
Powder
color 
White to light yellow or pinkish
Water Solubility 
Partly miscible with water.
BRN 
1854721
CAS DataBase Reference
1075-06-5(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
22-26-36
WGK Germany 
3
RTECS 
MD3260000
HS Code 
2914.40.4000
Toxicity
mouse,LD50,oral,500mg/kg (500mg/kg),Journal of Medicinal and Pharmaceutical Chemistry. Vol. 1, Pg. 365, 1959.

MSDS

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PHENYLGLYOXAL MONOHYDRATE Usage And Synthesis

Uses

Phenylglyoxal monohydrate was used to modify pig muscle carbonic anhydraseIII and as a specific reagent for arginine groups. It was also used to prepare pyrrolinone and furan derivatives and as as a chemiluminescent reagent for the determination of purines.

Biochem/physiol Actions

Phenylglyoxal is a potent inhibitor of mitochondrial aldehyde dehydrogenase. It reacts with arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties.

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