PHENYLGLYOXAL MONOHYDRATE Chemical Properties

Melting point:

76-79 °C(lit.)

Boiling point:

142 °C125 mm Hg(lit.)

Density 

1.1603 (rough estimate)

refractive index 

1.5120 (estimate)

Flash point:

142°C/125mm

storage temp. 

Sealed in dry,Room Temperature

solubility 

95% ethanol: soluble5%, clear to very slightly hazy, colorless to light yellow

pka

10.97±0.41(Predicted)

form 

Powder

color 

White to light yellow or pinkish

Water Solubility 

Partly miscible with water.

BRN 

1854721

CAS DataBase Reference

1075-06-5(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xn

Risk Statements 

22-36/37/38

Safety Statements 

22-26-36

WGK Germany 

3

RTECS 

MD3260000

HS Code 

2914.40.4000

Toxicity

mouse,LD50,oral,500mg/kg (500mg/kg),Journal of Medicinal and Pharmaceutical Chemistry. Vol. 1, Pg. 365, 1959.

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

PHENYLGLYOXAL MONOHYDRATE Usage And Synthesis

Uses

Phenylglyoxal monohydrate was used to modify pig muscle carbonic anhydraseIII and as a specific reagent for arginine groups. It was also used to prepare pyrrolinone and furan derivatives and as as a chemiluminescent reagent for the determination of purines.

Biochem/physiol Actions

Phenylglyoxal is a potent inhibitor of mitochondrial aldehyde dehydrogenase. It reacts with arginine residues in purified Hageman factor (HF, Factor XII) and causes inhibition of its coagulant properties.

Synthesis

GENERAL METHOD: Selenium dioxide (220 mg, 2 mmol) was dissolved in a mixed solution of 1,4-dioxane (1 mL) and deionized water (2 drops), followed by the addition of acetophenone 1a (120 mg, 1 mmol). The reaction mixture was refluxed with stirring for 7 h (the reaction progress was monitored by TLC, the unfolding agent was ethyl acetate/petroleum ether, 1:4, v/v). After completion of the reaction, it was cooled to room temperature, dichloromethane (5 mL) was added to the mixture and filtered through diatomaceous earth. The diatomaceous earth was washed with dichloromethane (3 x 5 mL). All organic phases were combined and concentrated under reduced pressure. The residue was purified by silica gel column chromatography with the eluent ethyl acetate/petroleum ether (1:10 v/v) to give benzoylformaldehyde hydrate 2a (121 mg, 80% yield). Compounds 2b~2m were synthesized following the same procedure in a range of 61%~82% yield.

References

[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 8, p. 1660 - 1664
[2] Tetrahedron Asymmetry, 2010, vol. 21, # 18, p. 2244 - 2248
[3] Tetrahedron, 2011, vol. 67, # 41, p. 8000 - 8008
[4] Chemistry of Heterocyclic Compounds, 2018, vol. 54, # 1, p. 51 - 57
[5] Khim. Geterotsikl. Soedin., 2018, vol. 54, # 1, p. 51 - 57,7

PHENYLGLYOXAL MONOHYDRATE(1075-06-5)Related Product Information

• Ethyl benzoylformate
• 4-O-(Carboxymethyl)rifamycin
• 4,4'-DIMETHOXYBENZIL
• Rifamycin Sodium
• α,α-Diethoxyacetophenone, Phenylglyoxal 2-diethyl acetal,PHENYLGLYOXAL DIETHYL ACETAL,PHENYLGLYOXAL 2-DIETHYL ACETAL
• 2-CHLORO-3' 4'-DIMETHOXYBENZIL 97
• 4-NITROPHENYLGLYOXYLIC ACID
• 2,2-Dimethoxy-2-phenylacetophenone
• Benzoylformic acid
• Ninhydrin hydrate
• DIETHOXYPHENYLACETOPHENONE
• 5-Nitroisatin
• POTASSIUM 1,2-NAPHTHOQUINONE-4-SULFONIC ACID
• 1-[4-(2-Oxo-2-phenylacetyl)phenyl]-2-phenylethane-1,2-dione
• Methyl benzoylformate
• 4-Bromophenylglyoxal hydrate
• 1,2-NAPHTHOQUINONE-4-SULFONIC ACID SODIUM SALT
• 3,3'-DIMETHOXYBENZIL