Isoxepac Chemical Properties

Melting point:

130-132°C

Boiling point:

528.2±50.0 °C(Predicted)

Density 

1.39 g/cm3

storage temp. 

Sealed in dry,Room Temperature

solubility 

soluble in Methanol

pka

4.24±0.10(Predicted)

form 

Solid

color 

White to Light yellow to Light orange

Merck 

14,5237

InChIKey

QFGMXJOBTNZHEL-UHFFFAOYSA-N

CAS DataBase Reference

55453-87-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

T

Risk Statements 

25-62

Safety Statements 

36/37-45

RIDADR 

UN 2811 6.1 / PGIII

RTECS 

HQ4110000

HazardClass 

6.1

PackingGroup 

III

HS Code 

2932996560

Toxicity

LD50 orally in rats: 199 mg/kg (Ueno)

Isoxepac Usage And Synthesis

Chemical Properties

Beige Solid

Uses

Isoxepac is a non-steroidal anti-inflammatory with analgesic and antipyretic activity. It is more slowly absorbed and eliminated in the rat and rabbit after oral dosing than in the dog, rhesus monkey and man.It can be used to treat allergic rhinitis, urticaria, and skin diseases with itching symptoms.

Definition

ChEBI: Isoxepac is a dibenzooxazepine.

Preparation

Isoxic acid is an important intermediate in the synthesis of the new preferred anti-allergic drug, olopatadine hydrochloride, preparation method of isoxepac:
(1) condensation: prepare p-hydroxyphenylaceticacid 8-12 part, phthalide 6-12 part, sodium methylate 8-12 part by weight; Dissolve with DMAC and to add said sodium methylate behind said p-hydroxyphenylaceticacid and the phthalide; Be that 0.1-10Pa is heated to 80-170 ℃ of reaction 3-10h at pressure then; Regulate the pH value to 1-5,4-(2-carboxyl benzyloxy) toluylic acid is separated out in crystallization;
(2) cyclization: with Glacial acetic acid min. 99.5 dissolving step (1) gained 4-(2-carboxyl benzyloxy) toluylic acid, adding 3-52 weight part polyphosphoric acid again, is that 0.1-10Pa is heated to 30-100 ℃ of reaction 3-12h at pressure, and crystallisation by cooling gets the Isoxepac bullion then;
(3) purify: behind the said Isoxepac bullion of acetic acid ethyl dissolution, refining decolouring gets the Isoxepac product.
https://patents.google.com/patent/CN102838582A/en

brand name

Artil(Hoechst-Roussel) .

Isoxepac(55453-87-7)Related Product Information

• Phenoxyacetic acid
• Ethyl 2-(Chlorosulfonyl)acetate
• Allyl phenoxyacetate
• 2-Hydroxyphenylacetic acid
• Triclopyr
• Fluroxypyr
• Dihydromyrcenol
• 4-Hydroxyphenylacetic acid
• Ethyl phenylacetate
• IXABEPILONE
• Ascoric Acid
• Olopatadine hydrochloride
• Olopatadine-d3 N-Oxide
• Olopatadine USP RC B
• Olopatadine Isopropyl ester Hydrochloride
• Olopatadine N-Oxide
• Olopatadine Impurity 1
• edoxaban