H-7 DIHYDROCHLORIDE Chemical Properties

Melting point:

215-225 °C

storage temp. 

2-8°C

solubility 

H₂O: 20 mg/mL

form 

Light yellow lyophilized solid

color 

White to Off-White

BRN 

5840763

CAS DataBase Reference

108930-17-2(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

F 

10

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

H-7 DIHYDROCHLORIDE Usage And Synthesis

Chemical Properties

White Crystalline Solid

Uses

A selective inhibitor of protein kinase C or cyclic-nucleotide-dependent protein kinases

Uses

H-7 dihydrochloride has been used to study H-7-induced inhibition of contractility in rat embryo fibroblasts (REF52) cells and acts as a kinase inhibitor.

Definition

ChEBI: A hydrochloride salt prepared from anileridine and two molar equivalents of hydrogen chloride.

General Description

A broad-based, cell-permeable, reversible, ATP-competitive serine-threonine kinase inhibitor. Potent inhibitor of myosin light chain kinase (K_i = 97 μM), protein kinase A (K_i = 3.0 μM), protein kinase C (K_i = 6 μM), and protein kinase G (K_i = 5.8 μM). Induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells. Also inhibits telomerase activity in quercetin-, H-89-, or herbimycin A-treated NPC-076 cells.

Biochem/physiol Actions

Target Ki: 3.0 μM, 97 μM, 6.0 μM, 5.8 μM against protein kinase A , myosin light chain kinase, protein kinase C , and protein kinase G, respectively

storage

Store at RT

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