Pomalidomide-PEG3-Amine HCl salt Chemical Properties

storage temp. 

2-8°C

form 

Solid

color 

Light yellow to yellow

InChI

1S/C21H28N4O7/c22-6-8-30-10-12-32-13-11-31-9-7-23-15-3-1-2-14-18(15)21(29)25(20(14)28)16-4-5-17(26)24-19(16)27/h1-3,16,23H,4-13,22H2,(H,24,26,27)

InChIKey

ALLUGXFCRRSPMS-UHFFFAOYSA-N

SMILES

O=C1NC(C(CC1)N2C(C3=C(C2=O)C(NCCOCCOCCOCCN)=CC=C3)=O)=O

Safety Information

WGK Germany 

WGK 3

Storage Class

11 - Combustible Solids

Pomalidomide-PEG3-Amine HCl salt Usage And Synthesis

Uses

Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Biological Activity

Pomalidomide 4'-PEG3-amine is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus a PEG3 linker with terminal amine ready for conjugation to a target protein ligand.

IC 50

Cereblon

storage

Desiccate at RT

References

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

Pomalidomide-PEG3-Amine HCl salt(2446474-09-3)Related Product Information

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