Pomalidomide-PEG3-Amine HCl salt
Pomalidomide-PEG3-Amine HCl salt Basic information
- Product Name:
- Pomalidomide-PEG3-Amine HCl salt
- Synonyms:
-
- Pomalidomide-PEG3-Amine HCl salt
- Pomalidomide-PEG3-Amine hydrochloride
- Pomalidomide-NH-PEG3-amine hydrochloride
- 4-((2-(2-(2-(2-aminoethoxy)ethoxy)ethoxy)ethyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
- Pomalidomide-PEG3-C2-NH2 hydrochloride
- Thalidomide-NH-PEG3-NH2 HCl
- Pomalidomide-PEG3-NH2.HCl
- Thalidomide-NH-PEG3-C2-NH2 hydrochloride
- CAS:
- 2446474-09-3
- MW:
- 484.93
- Product Categories:
-
- peg
- Mol File:
- 2446474-09-3.mol
Pomalidomide-PEG3-Amine HCl salt Chemical Properties
- storage temp.
- 2-8°C
- form
- Solid
- color
- Light yellow to yellow
Pomalidomide-PEG3-Amine HCl salt Usage And Synthesis
Uses
Pomalidomide-PEG3-C2-NH2 (Cereblon Ligand-Linker Conjugates 5) hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Biological Activity
Pomalidomide 4'-PEG3-amine is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus a PEG3 linker with terminal amine ready for conjugation to a target protein ligand.
IC 50
Cereblon
storage
Desiccate at RT
References
[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277
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