Basic information Safety Supplier Related

POMALIDOMIDE-PEG1-ALKYNE

Basic information Safety Supplier Related

POMALIDOMIDE-PEG1-ALKYNE Basic information

Product Name:
POMALIDOMIDE-PEG1-ALKYNE
Synonyms:
  • POMALIDOMIDE-PEG1-ALKYNE
MW:
0
Mol File:
Mol File
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POMALIDOMIDE-PEG1-ALKYNE Chemical Properties

storage temp. 
2-8°C
form 
powder or crystals
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POMALIDOMIDE-PEG1-ALKYNE Usage And Synthesis

Uses

Protein degrader builiding block Pomalidomide-PEG1-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

POMALIDOMIDE-PEG1-ALKYNESupplier

Sigma-Aldrich
Tel
021-61415566 800-8193336
Email
orderCN@merckgroup.com
Xi'an Confluore Biological Technology Co., Ltd.
Tel
+86-156-80926068 +86-15680926068
Email
1924344760@qq.com