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KARANJIN

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KARANJIN Basic information

Product Name:
KARANJIN
Synonyms:
  • 3-METHOXY-2-PHENYL-4H-FURO[2,3-H]-1-BENZOPYRAN-4-ONE
  • KARANJIN
  • karanjin from pongamia glabra oil
  • 2-Phenyl-3-methoxy-4H-furo[2,3-h]-1-benzopyran-4-one
  • Kranjin
  • 3-methoxy-2-phenyl-furo[2,3-h]chromen-4-one
  • 3-methoxy-2-phenylfuro[2,3-h]chromen-4-one
  • NSC 335755
CAS:
521-88-0
MF:
C18H12O4
MW:
292.29
EINECS:
208-319-9
Product Categories:
  • Flavanols
Mol File:
521-88-0.mol
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KARANJIN Chemical Properties

Melting point:
156°C
Boiling point:
463.0±45.0 °C(Predicted)
Density 
1.36
storage temp. 
2-8°C
solubility 
Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
form 
Solid
Specific Gravity
1.495
color 
White to Off-White
InChI
InChI=1S/C18H12O4/c1-20-18-15(19)13-7-8-14-12(9-10-21-14)17(13)22-16(18)11-5-3-2-4-6-11/h2-10H,1H3
InChIKey
LKPQNZRGGNOPPU-UHFFFAOYSA-N
SMILES
C1(C2=CC=CC=C2)OC2C3C=COC=3C=CC=2C(=O)C=1OC
LogP
3.290 (est)
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Safety Information

RTECS 
DX1500000

MSDS

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KARANJIN Usage And Synthesis

Chemical Properties

Needle-shaped crystal, soluble in methanol, ethanol, DMSO and other organic solvents, derived from water yellow skin, water Luo umbrella, water flow bean Pongamia pinnata, Mori fish vine Derris mollis. .

Uses

Aquaxanthin has an anti-tuberculosis effect.

Definition

ChEBI: Karanjin is an extended flavonoid.

Biological Activity

Karanjin is the main active furanoflavonol component in Fordia cauliflora. It induces GLUT4 translocation in skeletal muscle cells by increasing AMPK, and induces cancer cell death through cell cycle arrest and promotes apoptosis.

in vivo

Karanjin (50, 100 mg/kg, p.o., 6 h) reduces the blood glucose level of Streptozotocin (HY-13753)-induced diabetic rats[1].
Karanjin (20 mg/kg/d, p.o., 21 d) reduces joint injury and cartilage damage along with edema and erythema in the AIA model rats[1].
Karanjin (10, 20 mg/kg/d, p.o., 14 d) significantly decreases serum ACP, ALP and TNFα levels in the AIA model rats [1].
Karanjin (25 or 50 mg/kg/d, p.o. or i.g., 8 d) improved learning and memory in Diazepam-induced amnesia mice[1].

Animal Model:Streptozotocin-induced diabetic rats[1]
Dosage:50, 100 mg/kg
Administration:Oral gavage (p.o.), wait for 6h
Result:Lowered the blood glucose level by 11.7% and 20.7% at 50 and 100 mg/kg gavage.
Animal Model:Adjuvant induced arthritis model (AIA) Wistar strain male albino rats[1]
Dosage:10, 20 mg/kg/d
Administration:Oral gavage (p.o.), 14 d for serum assay, 21 d for histological examination
Result:Reduced articular cartilage damage, cellular infiltration in the articular cartilage and spongy bone damage significantly. Decreased serum acid phosphatase, alkaline phosphatase levels and TNFα level markedly.
Animal Model:Diazepam-induced male swiss albino mice [1]
Dosage:25, 50 mg/kg/d
Administration:Oral gavage (p.o.) or Intraperitoneal injection (i.p.) for 8 d
Result:Decreased the transfer latency on all the observation days, significantly reversed diazepam-induced amnesia, indicating improved learning and memory in treated mice.

KARANJINSupplier

Huzhou ZhanShu Biotechnology Co.,Ltd Gold
Tel
0572-8889530 18167260939
Email
zsubio@163.com
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Email
market03@meryer.com
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Email
info@chemlin.com.cn
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Email
cwb1@biopurify.cn
Shanghai Tauto Biotech Co., Ltd.
Tel
021-51320588
Email
tauto@tautobiotech.com
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