2,6-Dichloronicotinonitrile Chemical Properties

Melting point:

121-124 °C

Boiling point:

286.0±35.0 °C(Predicted)

Density 

1.49±0.1 g/cm3(Predicted)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

form 

powder to crystal

pka

-5.33±0.10(Predicted)

color 

White to Light yellow

Sensitive 

Moisture Sensitive

InChI

InChI=1S/C6H2Cl2N2/c7-5-2-1-4(3-9)6(8)10-5/h1-2H

InChIKey

LFCADBSUDWERJT-UHFFFAOYSA-N

SMILES

C1(Cl)=NC(Cl)=CC=C1C#N

Safety Information

Hazard Codes 

T

Risk Statements 

25-41-37/38

Safety Statements 

26-39-45

RIDADR 

UN 2811 6.1/PG 3

WGK Germany 

3

HazardClass 

6.1

PackingGroup 

Ⅲ

HS Code 

29333990

2,6-Dichloronicotinonitrile Usage And Synthesis

Chemical Properties

Brown yellow powder

Uses

2,6-Dichloro-3-cyanopyridine is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Synthesis Reference(s)

The Journal of Organic Chemistry, 44, p. 2693, 1979 DOI: 10.1021/jo01329a020

Synthesis

General procedure for the synthesis of 2,6-dichloronicotinonitrile from N-(2,6-dichloropyridin-3-yl)acetamide: To a solution of dichloromethane (100 mL) containing 2,6-dichloro-3-acetamidopyridine (6.3 g, 55% purity) and pyridine (4.93 mL, 61 mmol) was slowly added trifluoroacetic anhydride (4.23 mL, 30 mmol). The reaction mixture was stirred overnight at room temperature and subsequently concentrated under reduced pressure. The crude product was purified by fast chromatography using 85% hexane and 15% ethyl acetate as eluents to give a light yellow product (1.77 g, 90% yield).HPLC analysis showed a retention time of 10.26 min (90% purity) and mass spectrometry analysis showed the molecular ion peak [M+H]+ = 172.9, and the theoretical molecular weight for the molecular formula C6H2Cl2N2 was 171.9 g/mol.

References

[1] Patent: US2002/156087, 2002, A1

2,6-Dichloronicotinonitrile(40381-90-6)Related Product Information

• 2-Chloro-5-chloromethylpyridine
• 3-Cyanopyridine
• 3-Hydroxypyridine
• 2,6-Lutidine
• Dichloroethane
• 3-Aminopyridine
• 2,6-Dichloropyridine
• DICHLOROISOCYANURIC ACID
• Clopyralid
• Quinclorac
• Diisopropylammonium dichloroacetate
• 2-Chloro-3-cyanopyridine
• Thionyl chloride
• Sodium dichloroisocyanurate
• Dichlorodimethylsilane
• 1,3-Dichloropropene
• 1,2-Dichloroethane
• N,N-Dimethylacetamide