N-Hydroxyethylphthalimide Chemical Properties

Melting point:

126-128 °C(lit.)

Boiling point:

326.92°C (rough estimate)

Density 

1.2722 (rough estimate)

refractive index 

1.5310 (estimate)

storage temp. 

Inert atmosphere,Room Temperature

solubility 

DMSO (Slightly), Methanol (Slightly)

form 

Crystalline Powder

pka

14.40±0.10(Predicted)

color 

White

BRN 

147214

InChIKey

MWFLUYFYHANMCM-UHFFFAOYSA-N

CAS DataBase Reference

3891-07-4(CAS DataBase Reference)

NIST Chemistry Reference

N-2-hydroxyethyl phthalimide(3891-07-4)

EPA Substance Registry System

1H-Isoindole-1,3(2H)-dione, 2-(2-hydroxyethyl)- (3891-07-4)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

22-26-36/37/39-24/25

WGK Germany 

3

TSCA 

Yes

HS Code 

29251900

MSDS

• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

N-Hydroxyethylphthalimide Usage And Synthesis

Chemical Properties

white crystalline powder

Uses

N-(2-Hydroxyethyl)phthalimide is used as a reagent to synthesize (-)-R-rolipram is a phosphodiesterase 4 inhibitor that is used to treat depression. N-(2-Hydroxyethyl)phthalimide is also used as a reagent to synthesize FR252921, a compound that acts as an immunosuppressant. Amlodipine Impurity 6

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 4, p. 106, 1963
The Journal of Organic Chemistry, 24, p. 1122, 1959 DOI: 10.1021/jo01090a601

General Description

N-(2-Hydroxyethyl)phthalimide is the precursor for chloromethyl ethers used in the synthesis of purine acyclic nucleosides.

N-Hydroxyethylphthalimide(3891-07-4)Related Product Information

• 3-Nitrophthalimide
• Bismaleimide
• N-Methylphthalimide
• Succinimide
• 4-Nitrophthalimide
• 2-(METHYLSULFONYL)ETHANOL
• Methyl 2-hydroxyethyl cellulose
• Hydroxyethyl starch
• Hydroxyethyl Cellulose
• O-Phthalimide
• Potassium phthalimide
• 4-Aminophthalimide
• N-Hydroxyphthalimide
• Aztreonam Amide
• N-CHLOROSACCHARIN
• N-(Hydroxymethyl)phthalimide
• Desmethyl amolodipine
• Amlodipine Impurity 26