2-Chloro-3-fluoronitrobenzene Chemical Properties

Boiling point:

237-239 °C

Density 

1.494±0.06 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

form 

low melting solid

color 

Brown

CAS DataBase Reference

21397-07-9(CAS DataBase Reference)

Safety Information

Hazard Codes 

T

HS Code 

2904990090

2-Chloro-3-fluoronitrobenzene Usage And Synthesis

Uses

2-Chloro-3-fluoronitrobenzene can be used in substitution reactions to prepare other organic heterocyclic compounds. Its derivatives are also used as raw materials for the synthesis of aromatic polyimides.

Synthesis

General procedure for the synthesis of 2-chloro-3-fluoronitrobenzene from 3-fluoronitrobenzene: To a solution of 3-fluoronitrobenzene (2 g, 14.2 mmol) in tetrahydrofuran (THF, 30 mL) was slowly added a solution of N-chlorosuccinimide (5.69 g, 42.6 mmol) in THF (20 mL) at -78 °C. Subsequently, NaHMDS (28.4 mL, 28.4 mmol) in a 1 M solution of THF was added dropwise while ensuring that the internal temperature of the reaction system was maintained below -75 °C. The reaction mixture was stirred continuously at -78 °C for 30 min. Upon completion of the reaction, the mixture was partitioned between 5% hydrochloric acid and ethyl acetate. The organic layers were combined, dried with anhydrous magnesium sulfate (MgSO4), filtered and the solvent evaporated. The resulting solid was purified by silica gel column chromatography with the eluent being a hexane solution of 20% ethyl acetate, resulting in the target product 2-chloro-3-fluoronitrobenzene (231 mg, 9.2% yield). The structure of the product was confirmed by EI-MS, m/z 176.5 (M+).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 15, p. 3365 - 3369
[2] Journal of Organic Chemistry, 2011, vol. 76, # 9, p. 3416 - 3437
[3] Patent: US6500863, 2002, B1
[4] Patent: US6500863, 2002, B1

2-Chloro-3-fluoronitrobenzene(21397-07-9)Related Product Information

• 4-Fluoronitrobenzene
• Cyhalothrin
• 1-Chloro-3-nitrobenzene
• 1-Fluoro-2-nitrobenzene
• λ-Cyhalothrin
• 2-Nitrochlorobenzene
• Difluorochloromethane
• Fluorine
• 2-Chloro-5-fluoronitrobenzene 99%,2-Chloro-5-fluoronitrobenzene99%,2-CHLORO-5-FLUORONITROBENZENE
• 1,2-DICHLORO-4-FLUORO-5-NITROBENZENE
• 2-CHLORO-6-FLUORONITROBENZENE
• Nitrobenzene
• 4-Chloronitrobenzene
• 2,4-Dichloro-5-fluoro-3-nitrobenzoic acid
• 2-Chloro-3,4-difluoronitrobenzene
• 4-CHLORO-3-FLUORONITROBENZENE
• 3-CHLORO-2-FLUORONITROBENZENE / 1-CHLORO-2-FLUORO-3-NITROBENZENE,3-CHLORO-2-FLUORONITROBENZENE
• 3-CHLORO-4-FLUORONITROBENZENE,3-Chloro-4-fluoronitrobenzene98%,3-Chloro-4-fluoronitrobenzene 98%