METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE
METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE Basic information
- Product Name:
- METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE
- Synonyms:
-
- Methyl 4-(bromomethyl)-3-methoxybenzonate
- 4-BROMOMETHYL-3-METHOXY-BENZOIC ACID METHYL ESTER
- METHYL3-METHOXY-4-(BROMOMETHYL)BENZONATE
- METHYL4-BROMOETHYL-3-METHOXYBENZOATE
- 4-Brommethyl-3-methoxybenzoesuremethylester
- Methyl 4-brome methyl-3-methoxy benzoate
- Methyl 4-(bromomethyl)-3-(methyloxy)benzoate
- Methyl 4-(bromomethyl)-3-methoxybenzoate 98%
- CAS:
- 70264-94-7
- MF:
- C10H11BrO3
- MW:
- 259.1
- EINECS:
- 410-310-1
- Product Categories:
-
- Building Blocks
- C10 to C11
- Aromatic Esters
- Carbonyl Compounds
- Chemical Synthesis
- Organic Building Blocks
- Benzoic acid
- C10 to C11
- Carbonyl Compounds
- Esters
- Mol File:
- 70264-94-7.mol
METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE Chemical Properties
- Melting point:
- 92-94°C
- Boiling point:
- 324.2±32.0 °C(Predicted)
- Density
- 1.432
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- Chloroform (Sparingly), Methanol (Slightly)
- form
- powder to crystal
- color
- White to Light yellow
- CAS DataBase Reference
- 70264-94-7(CAS DataBase Reference)
Safety Information
- Hazard Codes
- Xi,N
- Risk Statements
- 36/37/38-50/53-43-41-38
- Safety Statements
- 26-36/37/39-61-60
- RIDADR
- UN 2811 6.1/PG 3
- WGK Germany
- 3
- HazardClass
- IRRITANT
- PackingGroup
- Ⅲ
- HS Code
- 2918999090
METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE Usage And Synthesis
Preparation
Methyl 4-(bromomethyl)-3-methoxybenzoate is prepared by the following steps:A mixture of methyl 3-methoxy-4-methylbenzoate 37 (5 g, 27.8 mmol), NBS (4.94 g, 27.8 mmol), and benoyl peroxide (0.0008 g, 0.003 mmol) was refluxed in CCl4 (25 ml) for 10 hours. The reaction mixture was allowed to cool and filtered. The residue was washed with CCl4 and the combined filtrate concentrated in vacuo. Purification by column chromatography over silica gel (5-10% EtOAc-pet ether) furnished a colourless solid (7.19 g).Yield : 100%
Uses
Methyl 4-(Bromomethyl)-3-methoxybenzoate is an intermediate used to prepare heteroarylphenyloxoacetyl and heteroarylphenylsulfonyl benzoylpiperazine analogs of BMS 378806 as HIV entry inhibitors. It is also used to synthesize steroid 5α-reductase inhibiting acylpiperidines.
METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE Preparation Products And Raw materials
Raw materials
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METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE(70264-94-7)Related Product Information
- methyl 4-(bromomethyl)-2-methoxybenzoate
- METHYL-3-BROMOMETHYL-5-METHOXYBENZOATE
- 4-Methylbenzyl bromide
- 4-Bromomethylbenzoic acid
- Methyl 4-(bromomethyl)benzoate
- 3-METHOXY-4-METHYLBENZALDEHYDE
- METHYL 3-METHOXY-4-METHYLBENZOATE
- METHYL 3-HYDROXY-4-METHYLBENZOATE
- 2-(BROMOMETHYL)PHENOL
- 1-(bromomethyl)-2-methoxybenzene
- 3-Hydroxy-4-methylbenzoic acid
- 4-(BROMOMETHYL)BENZALDEHYDE
- 3-Methoxy-4-methylbenzoic acid
- METHYL 4-(BROMOMETHYL)-3-METHOXYBENZOATE