3-METHOXY-4-METHYLBENZALDEHYDE Chemical Properties

Melting point:

40.5-41.5

Boiling point:

246.2±20.0 °C(Predicted)

Density 

1.062±0.06 g/cm3(Predicted)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

powder

color 

Yellow to light beige

CAS DataBase Reference

24973-22-6(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36/37/39-45-22

HS Code 

29122990

3-METHOXY-4-METHYLBENZALDEHYDE Usage And Synthesis

Chemical Properties

solid

Synthesis Reference(s)

Journal of Medicinal Chemistry, 32, p. 2210, 1989 DOI: 10.1021/jm00129a029

Synthesis

Dess-Martin periodinane (3 g, 7.07 mmol) was slowly added to a solution of (3-methoxy-4-methylphenyl)methanol (1 g, 6.57 mmol) in dichloromethane (35 mL) at 0 °C. The reaction mixture was stirred continuously at 0°C for 0.5 hours. Subsequently, a portion of the dichloromethane was concentrated under reduced pressure, and the reaction mixture was diluted with ether and washed sequentially with saturated sodium bicarbonate solution, sodium thiosulfate solution and water. The organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to obtain 3-methoxy-4-methylbenzaldehyde in quantitative yield.

References

[1] Patent: WO2006/110668, 2006, A1. Location in patent: Page/Page column 65
[2] Journal of Medicinal Chemistry, 2012, vol. 55, # 15, p. 6948 - 6957
[3] Chemical and Pharmaceutical Bulletin, 1990, vol. 38, # 7, p. 1852 - 1856
[4] Journal of Medicinal Chemistry, 1989, vol. 32, # 9, p. 2210 - 2214
[5] Organic and Biomolecular Chemistry, 2015, vol. 13, # 37, p. 9564 - 9569

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