Glycyl-glycyl-glycine Chemical Properties

Melting point:

240-250 °C

Boiling point:

324.41°C (rough estimate)

Density 

1.4204 (rough estimate)

refractive index 

1.5250 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

H₂O: 0.5 M at 20 °C, clear, colorless

pka

3.225(at 25℃)

form 

Solid

color 

White to Off-White

PH

4.5-6.0 (25℃, 0.5M in H2O)

Water Solubility 

Soluble in water (94.6 mg/ml at 20°C), methanol (50 mg/ml), and 80% acetic acid (50 mg/ml).

λmax

λ: 260 nm Amax: 0.15
λ: 280 nm Amax: 0.10

Merck 

14,6579

BRN 

1711130

InChIKey

XKUKSGPZAADMRA-UHFFFAOYSA-N

CAS DataBase Reference

556-33-2(CAS DataBase Reference)

NIST Chemistry Reference

N-(N-Glycylglycyl)glycine(556-33-2)

Safety Information

WGK Germany 

3

F 

3-10

HS Code 

29241990

MSDS

• Language:English Provider:Glycyl-glycyl-glycine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

Glycyl-glycyl-glycine Usage And Synthesis

Chemical Properties

White prismatic crystals or powder cannot coexist with strong oxidizing agents, aluminum, copper, copper alloy, and nickel. Glycyl-glycyl-glycine has a strong complexing ability and can form stable chelates with different metal ions due to its small molecule size and ability to provide four coordination bonds for metal ions.

Uses

Glycyl-glycyl-glycine is used as a model peptide for studies of physicochemical parameters and molecular associations of small peptides. It is also used as a copper chelator and Substrate for tripeptide aminopeptidase.

Application

Glycyl-glycyl-glycine is commonly used in the food, pharmaceutical, and cosmetic industries as an ingredient in skin and hair care products. It is also used as a dietary supplement due to its ability to improve digestion and promote the growth of healthy gut bacteria.

Definition

ChEBI: Glycyl-glycyl-glycine is a tripeptide in which three glycine units are linked via peptide bonds in a linear sequence. It is a tautomer of a Gly-Gly-Gly zwitterion.

General Description

Gly-Gly-Gly or triglycine is a flexible peptide linker with three glycine residues linked by peptide bonds in a linear sequence. Gly-linkers link multiple domains in a single protein without affecting the function of each domain.

Biochem/physiol Actions

Substrate for reproducible serum protein measurements by the biuret reaction and for the assay of aminotripeptidases.

Purification Methods

Crystallise triglycine from H2O or H2O/EtOH and dry it at 110o. [Yakel & Hughes Acta Cryst 5 847 1952, Lenel et al. Acta Cryst 3 313 1952, Holley & Holley J Am Chem Soc 74 3072 1952, Beilstein 4 III 1198, 4 IV 2469.]

Glycyl-glycyl-glycine(556-33-2)Related Product Information

• EC 2.3.2.2
• L-Alanyl-L-Glutamine
• Glycylglycine
• Glycine
• Glycyl-glycyl-glycyl-glycine, Tetraglycine, Triglycyl-glycine,GLYCYL-GLYCYL-GLYCYL-GLYCINE
• Glycylglycyl-L-isoleucine
• N-Glycyl-L-tyrosine
• Gly-Gly-Leu
• Glycyl-glycyl-L-valine
• Glycyl-L-valine
• GLY-GLY BENZYL ESTER P-TOLUENESULFONATE SALT
• glycyl-glycyl-proline
• H-Gly-Gly-Tyr-OH.HCl
• GLYCYLGLYCINE ETHYL ESTER HYDROCHLORIDE
• GLYCYLGLYCINE METHYL ESTER HYDROCHLORIDE
• Glycinamide hydrochloride
• H-GLY-GLY-PHE-OH
• H-GLY-NHME HCL