1-Chloro-N,N,2-trimethylpropenylamine Chemical Properties

Boiling point:

129-130 °C(lit.)

Density 

1.01 g/mL at 25 °C(lit.)

refractive index 

n20/D 1.453(lit.)

Flash point:

80 °F

storage temp. 

2-8°C

solubility 

Chloroform (Sparingly), Methanol (Slightly)

form 

Liquid

pka

4.27±0.70(Predicted)

color 

Colorless to yellow

Stability:

Hygroscopic, Moisture Sensitive, Unstable in Solution

Safety Information

Hazard Codes 

C

Risk Statements 

10-34

Safety Statements 

16-26-36/37/39-45

RIDADR 

UN 2734 8/PG 1

WGK Germany 

3

HS Code 

29211990

MSDS

• Language:English Provider:ACROS
• Language:English Provider:SigmaAldrich

1-Chloro-N,N,2-trimethylpropenylamine Usage And Synthesis

Chemical Properties

Colorless to yellow liquid

Uses

1-Chloro-N,N,2-trimethyl-1-propenylamine is an acid halogenation reagent developed by Ghosez, that enables the conversion of carboxylic acids into the corresponding chlorides under strictly neutral conditions. This method was successfully used in the total synthesis of caloporoside, roseophilin, (-)-enniatin B, (±)-epimeloscine and (±)-meloscine.

Synthesis Reference(s)

Journal of the American Chemical Society, 94, p. 2869, 1972 DOI: 10.1021/ja00763a061
Organic Syntheses, Coll. Vol. 6, p. 282, 1988
Tetrahedron Letters, 25, p. 5043, 1984 DOI: 10.1016/S0040-4039(01)91114-1

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