Basic information Safety Supplier Related

Diloxanide furoate

Basic information Safety Supplier Related

Diloxanide furoate Basic information

Product Name:
Diloxanide furoate
Synonyms:
  • 2,2-DICHLORO-N-(4-HYDROXYPHENYL)-N-METHYLACETAMIDE 2-FUROIC ACID ESTER
  • DILOXANIDE FUROATE
  • 2-furancarboxylicacid,4-((dichloroacetyl)methylamino)phenylester
  • 2-furoicacid,esterwith2,2-dichloro-4’-hydroxy-n-methylacetanilide
  • 8073cb
  • amebiazol
  • dichlofurazol
  • diclofurazol
CAS:
3736-81-0
MF:
C14H11Cl2NO4
MW:
328.15
EINECS:
223-108-1
Mol File:
3736-81-0.mol
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Diloxanide furoate Chemical Properties

Melting point:
111-114 °C
Boiling point:
438.4±45.0 °C(Predicted)
Density 
1.424±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
Chloroform (Slightly), Methanol (Slightly)
form 
Solid
pka
-0?+-.0.50(Predicted)
color 
Off-White to Light Beige
BCS Class
4
CAS DataBase Reference
3736-81-0(CAS DataBase Reference)
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
36
WGK Germany 
3
RTECS 
LV1821800
HS Code 
2924296000
Toxicity
mouse,LDLo,oral,710mg/kg (710mg/kg),Archives of Environmental Contamination and Toxicology. Vol. 14, Pg. 111, 1985.

MSDS

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Diloxanide furoate Usage And Synthesis

Uses

selective agonist for delta-opioid receptor

Uses

Antidiarrhoeals / Antiprotozoles

Uses

Furamide is an ambecide, an anti-protozoal drug used in the treatment of amoebozoa infections.

Definition

ChEBI: Diloxanide furoate is a carboxylic ester resulting from the formal condensation of the carboxy group of furan-2-carboxylic acid with the hydroxy group of 2,2-dichloro-N-(4-hydroxyphenyl)-N-methylacetamide. It is a drug used for the treatment of asymptomatic amebiasis. It has a role as an antiamoebic agent and a prodrug. It is a member of furans, a carboxylic ester, a tertiary carboxamide and an organochlorine compound.

Indications

Diloxanide furoate (Furamide) is an amebicide that is effective against trophozoites in the intestinal tract. In mild or asymptomatic infections, cures of 83 to 95% have been achieved; in patients with dysentery, cure rates may be less impressive. The drug is administered only orally and is rapidly absorbed from the gastrointestinal tract following hydrolysis of the ester group. It is remarkably free of side effects, but occasionally flatulence, abdominal distention, anorexia, nausea, vomiting, diarrhea, pruritus, and urticaria occur. Diloxanide is excreted in the urine, largely as the glucuronide. It is not available in the United States.

Clinical Use

Diloxanide furoate (available from the Centers for Disease Control and Prevention [CDC]) is prescribed for the treatment of asymptomatic amebiasis but is ineffective as a single agent for the extraintestinal form of the disease. The drug is administered orally and is hydrolyzed in the gut to give diloxanide, which is considered to be the active drug. Diloxanide is the only form identified in the bloodstream. The drug is found in the urine as the glucuronide.

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