CIS-3,3,5-TRIMETHYLCYCLOHEXANOL Chemical Properties

Melting point:

35-38 °C

Boiling point:

196.5 °C

Density 

0.8908 g/cm³ (25 ºC)

vapor pressure 

40Pa at 20℃

refractive index 

1.4542 (589.3 nm 20℃)

FEMA 

3962 | 3,5,5-TRIMETHYLCYCLOHEXANOL

Flash point:

88 °C

form 

powder to lump to clear liquid

pka

15.35±0.60(Predicted)

color 

White or Colorless to Almost white or Almost colorless

Odor

at 100.00?%. minty

Water Solubility 

1.45g/L at 20℃

Cosmetics Ingredients Functions

PERFUMING

LogP

2.86 at 23℃

EPA Substance Registry System

cis-3,3,5-Trimethylcyclohexanol (933-48-2)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36

Safety Statements 

39-26

RTECS 

GW0876000

TSCA 

TSCA listed

HS Code 

2906.19.5000

MSDS

• Language:English Provider:ACROS

CIS-3,3,5-TRIMETHYLCYCLOHEXANOL Usage And Synthesis

Uses

cis-3,3,5-trimethylcyclohexanol (cis-3,3,5-trimethylcyclohexanol) is used as a cyclomandelate drug intermediate in laboratory research and development and in chemical and pharmaceutical synthesis.

Chemical Properties

WHITE CRYSTALLINE MASS

Synthesis

A method for the synthesis of cis-3,3,5-trimethylcyclohexanol (cis-3,3,5-trimethylcyclohexanal), a pharmaceutical intermediate of cyclobenzolate, was carried out according to the following steps: A. To a reaction vessel was added 1,5,5-trimethylcyclohexen-3-one (2) 0.51 mol, 600 ml of a solution of 2-amino-5-chlorobenzoic acid with a mass fraction of 37%, the temperature of the solution was lowered to 0??C, and the stirring speed was controlled at 110 rpm; B, slowly add lithium powder 1.38mol, adding time control at 120min, after adding continue to react for 90min, and then slowly raise the temperature to 16 ??, the heating process control at 50min; C, solution concentration under reduced pressure, the concentrate was added to 230ml of potassium bromide solution with a mass fraction of 28%, add 100ml of oxalic acid solution with a mass fraction of 38%, dimethylamine solution with a mass fraction of 57% was extracted for 7 times, the extracts were combined, washed sequentially with ethyl acetate solution with a mass fraction of 48%, butanone solution with a mass fraction of 60%, dewatered with calcium chloride dewatering agent. 1.7 kPa distillation under reduced pressure, the fraction at 80-86 ??C was collected and recrystallized in 88% mass fraction of cyclohexane solution to obtain crystalline cis-3,3,5-trimethylcyclohexanol (cis-3,3,5-trimethylcyclohexanal) 64.45 g, yield 89%.

CIS-3,3,5-TRIMETHYLCYCLOHEXANOL(933-48-2)Related Product Information

• Maslinic acid
• Madecassoside
• DIHYDROOUABAIN
• ECHINOCYSTIC ACID-3-GLUCOSIDE
• 11ALPHA-HYDROXYPROGESTERONE
• 11ALPHA-HYDROXYPROGESTERONE ACETATE
• ECHINOCYSTIC ACID
• Hyodeoxycholic acid
• 3,3,5,5-TETRAMETHYLCYCLOHEXANOL
• CAULOPHYLLOGENIN
• 1,3,3,5,5-PENTAMETHYLCYCLOHEXANOL
• G-STROPHANTHIN
• TRANS-3,3,5-TRIMETHYLCYCLOHEXANOL
• METHYLCYCLOHEXANOL
• 3,3,5-Trimethylcyclohexanol
• 11-ALPHA-HYDROXY-4-PREGNENE-3,20-DIONE 11-HEMISUCCINATE
• 5-BETA-PREGNAN-3-ALPHA, 6-ALPHA-DIOL-20-ONE
• 5-BETA-PREGNAN-3-ALPHA, 11-ALPHA, 17,20-ALPHA-TETROL