Dostarlimab
Dostarlimab Basic information
- Product Name:
- Dostarlimab
- Synonyms:
-
- Dostarlimab
- Research Grade Dostarlimab (DHH02205)
- TSR-042
- Dostarlimab (anti-PD-1)
- Research Grade Dostarlimab
- CAS:
- 2022215-59-2
- MW:
- 0
- Mol File:
- Mol File
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Dostarlimab Chemical Properties
- form
- Liquid
- color
- Colorless to light yellow
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Dostarlimab Usage And Synthesis
Uses
Dostarlimab (TSR-042) is a humanized anti-PD-1 monoclonal antibody. Dostarlimab binds with high affinity to human PD-1 and competitively inhibits its interaction with its ligands, PD-L1 and PD-L2, with IC50s of 1.8 and 1.5 nM, respectively[1].
in vivo
Dostarlimab (200 μg/mouse; i.p.; twice weekly for 35 days) shows antitumor activity in humanized mouse models[1].
| Animal Model: | Humanized NOG-EXL mice, A549 and MDA-MB-436 tumor model[1] |
| Dosage: | 200 μg/mouse |
| Administration: | Intraperitoneal injection; twice weekly for 35 days |
| Result: | Resulted in great inhibition of tumor growth in an A549 lung cancer model (tumor growth inhibition [TGI] of 62% at termination). The antitumor activity was associated with a reduction in tumor-associated regulatory T cells and a trend toward increased tumor-infiltrating CD8+ T cells. Inhibited tumor growth of MDA-MB-436 breast cancer model (TGI of 53%). |
References
[1] Kumar S, et al. Preclinical characterization of dostarlimab, a therapeutic anti-PD-1 antibody with potent activity to enhance immune function in in vitro cellular assays and in vivo animal models. MAbs. 2021 Jan-Dec;13(1):1954136. DOI:10.1080/19420862.2021.1954136
DostarlimabSupplier
Shanghai YuanYe Biotechnology Co., Ltd.
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- 021-61312847; 18021002903
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ShangHai Biochempartner Co.,Ltd
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- 177-54423994 17754423994
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Guangzhou Hongyuan Chemical Co.,Ltd
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- 15817493340
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Wuhan Chemstan Biotechnology Co., Ltd.
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- 027-65317797 15926423062
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TargetMol Chemicals Inc.
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- 4008200310
- marketing@tsbiochem.com