TERT-BUTOXYCARBONYLAMINO-ACETIC ACID ETHYL ESTER Chemical Properties

Boiling point:

97°C/0.7mmHg(lit.)

Density 

1.053±0.06 g/cm3(Predicted)

refractive index 

1.4350 to 1.4390

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

pka

11.18±0.46(Predicted)

form 

Oily Liquid

color 

Colorless

InChI

InChI=1S/C9H17NO4/c1-5-13-7(11)6-10-8(12)14-9(2,3)4/h5-6H2,1-4H3,(H,10,12)

InChIKey

CNIBHMMDDXGDNR-UHFFFAOYSA-N

SMILES

C(OCC)(=O)CNC(OC(C)(C)C)=O

Safety Information

HS Code 

2924297099

TERT-BUTOXYCARBONYLAMINO-ACETIC ACID ETHYL ESTER Usage And Synthesis

Uses

Ethyl (tert-Butoxycarbonyl)glycinate is a Glycine.html" class="link-product" target="_blank">Glycine (HY-Y0966) derivative[1].

Synthesis

1. A solution of di-tert-butyl dicarbonate (365 g, 1.67 mol) in tetrahydrofuran (1 L) was slowly added dropwise to a solution of tetrahydrofuran (2.5 L) containing ethyl glycinate hydrochloride (232.5 g, 1.66 mol) and triethylamine (497.5 ml, 3.57 mol) at 0 °C. 2. The reaction mixture was allowed to react for 36 hours under vigorous stirring. 3. . After completion of the reaction, the reaction mixture was filtered.4. The filtrate was concentrated under vacuum to give 329.49 g (98% yield) of ethyl N-tert-butoxycarbonylglycinate (compound 5) as a white solid.

References

[1] Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. DOI:10.1080/10408398.2012.708368

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