2-Amino-3-(trifluoromethyl)pyridine Chemical Properties

Melting point:

70-72°C

Boiling point:

203.2±35.0 °C(Predicted)

Density 

1.368±0.06 g/cm3(Predicted)

storage temp. 

Keep in dark place,Inert atmosphere,Room temperature

pka

4.18±0.36(Predicted)

form 

solid

color 

Off-white

InChIKey

YWOWJQMFMXHLQD-UHFFFAOYSA-N

CAS DataBase Reference

183610-70-0(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi,T

Risk Statements 

25-36-43

Safety Statements 

26-36/37/39

RIDADR 

2811

WGK Germany 

3

Hazard Note 

Irritant

HazardClass 

6.1

PackingGroup 

Ⅲ

HS Code 

29333990

2-Amino-3-(trifluoromethyl)pyridine Usage And Synthesis

Uses

2-?Amino-?3-?(trifluoromethyl)?pyridine is a reagent used in the preparation of novel propanamide derivatives functioning as fatty acid amide inhibitors.

Synthesis

The general procedure for the synthesis of 2-amino-3-trifluoromethylpyridine from 2-fluoro-3-trifluoromethylpyridine was as follows: 750 g of 2-fluoro-3-trifluoromethylpyridine and 700 g of water were added sequentially to an ammonia reactor, followed by the slow addition of 250 g of liquid ammonia. The reaction system was heated up to 130 °C, and the reaction pressure was maintained at a set value for 10 hours. Upon completion of the reaction, the system was cooled to 90 °C and the reaction mixture was transferred to a receiving kettle. After further cooling to 10 °C, the solid product was obtained by centrifugation and dried to obtain 2-amino-3-trifluoromethylpyridine in about 95% yield.

References

[1] Patent: CN108003093, 2018, A. Location in patent: Paragraph 0008; 0017-0018; 0020-0021; 0023-0024

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