(R)-1-[(S)-2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]PHOSPHINO]FERROCENYL]-ETHYLDI-TERT-BUTYLPHOSPHINE Chemical Properties

alpha 

-352° ±10° (c 0.5, CHCl3)

storage temp. 

under inert gas (nitrogen or Argon) at 2-8°C

form 

Powder

color 

orange

Safety Information

Risk Statements 

36/37/38

Safety Statements 

24/25

WGK Germany 

3

HS Code 

29319090

MSDS

• Language:English Provider:ACROS

(R)-1-[(S)-2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]PHOSPHINO]FERROCENYL]-ETHYLDI-TERT-BUTYLPHOSPHINE Usage And Synthesis

Reaction

1. Ferrocenylphosphine ligands of the type cpFecp(PR2)(*CH(CH3)PR'2) are a class of asymmetric ligands developed at Solvias in Basel, Switzerland. Ligands of this type are currently used industrially in the stereoselective synthesis of commercial products. A unique feature of these bidentate ligands is the presence of a fixed phosphine moiety and a stereogenic, functionalized side chain, which can be easily modified to accommodate electronic and steric requirements. Based on a versatile synthetic procedure starting with optically active ferrocenes of the type cpFecp(PR2)(*CH(CH3)X) [X = OAc or NR2], a variety of donor atoms can be introduced into the side chain. These ferrocene based phosphine ligands have wide application in the stereoselective hydrogenation of substituted acetamidoacrylates, enol acetates, β-ketoesters and simple alkenes.
2. Useful as a ligand in Pd-catalyzed C-N bond-forming reactions.
3. Pd-catalyzed enantioselective alkylative desymmetrization of meso-succinic anhydrides.
4. Asymmetric hydrogenation of ketones and phosphinylketimines.
5. Michael addition of Grignard reagents to α,α-unsaturated esters and thioesters.
6. Boration of α,α-unsaturated esters and nitriles.
7. Reaction of aryl halides with ammonia.
8. Cu-catalyzed reduction of activated C=C bonds with PMHS.
9. Regio- and enantioselective hydroboration of vinyl arenes.
10. Rh-catalyzed asymmetric ring-opening reactions of oxabicyclic alkenes.
11. 1,2-Migrations in Pd-catalyzed Negishi couplings with JosiPhos ligands.
12. Catalyst for the homodimerization of ketoketenes.
13. Ligand for the Rh catalyzed synthesis of lactones.
14. Ligand for the Cu-catalyzed synthesis of syn and anti γ-amino alcohols.

(R)-1-[(S)-2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]PHOSPHINO]FERROCENYL]-ETHYLDI-TERT-BUTYLPHOSPHINE(246231-79-8)Related Product Information

• (S)-1-{(R)-2-[DI(2-FURYL)PHOSPHINO]FERROCENYL}ETHYLDI-TERT.-BUTYLPHOSPHINE
• (R)-(-)-1-[(S)-2-(DI(3,5-BIS-TRIFLUOROMETHYLPHENYL)PHOSPHINO)FERROCENYL]ETHYLDI(3,5-DIMETHYLPHENYL)PHOSPHINE
• (R)-(-)-1-[(S)-2-(DIPHENYLPHOSPHINO)FERROCENYL]ETHYLDI(3,5-DIMETHYLPHENYL)PHOSPHINE
• (R)-(-)-1-[(S)-2-(DI(3,5-DIMETHYL-4-METHOXYPHENYL)PHOSPHINO)FERROCENYL]ETHYLDICYCLOHEXYLPHOSPHINE
• (R)-(S)-JOSIPHOS
• (R)-1-[(1S)-2-(DICYCLOHEXYLPHOSPHINO)FERROCENYL]ETHYLDICYCLOHEXYLPHOSPHINE
• (R)-(-)-1-[(S)-2-(DI(3,5-BIS-TRIFLUOROMETHYLPHENYL)PHOSPHINO)FERROCENYL]ETHYLDICYCLOHEXYLPHOSPHINE
• (R)-1-[(S)-2-[BIS[4-(TRIFLUOROMETHYL)PHENYL]PHOSPHINO]FERROCENYL]-ETHYLDI-TERT-BUTYLPHOSPHINE
• (R)-1-[(1S)-2-(DIPHENYLPHOSPHINO)FERROCENYL]ETHYLDI-TERT-BUTYLPHOSPHINE
• Ferrocene
• Phosphine
• 1,3-Cyclopentadiene
• T-BUTYLPHOSPHINE
• Di-tert-butylphosphine
• DI-T-BUTYL(I-PROPYL)PHOSPHINE
• TERT-BUTYLDIISOPROPYLPHOSPHINE
• BIS(4-TRIFLUOROMETHYLPHENYL)PHOSPHINE
• (4-TRIFLUOROMETHYLPHENYL)PHOSPHINE