2-Iodoaniline Chemical Properties

Melting point:

55-58 °C (lit.)

Boiling point:

262.0±23.0 °C(Predicted)

Density 

1.8155 (estimate)

Flash point:

>230 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

soluble in Chloroform, DCM, Ethyl Acetate, Toluene

form 

Crystalline Needles

pka

2.6(at 25℃)

color 

Yellow to brown

Water Solubility 

Insoluble in water.

Sensitive 

Light Sensitive

BRN 

2204899

InChIKey

UBPDKIDWEADHPP-UHFFFAOYSA-N

CAS DataBase Reference

615-43-0(CAS DataBase Reference)

NIST Chemistry Reference

Benzenamine, 2-iodo-(615-43-0)

EPA Substance Registry System

o-Iodoaniline (615-43-0)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

20/21/22-37/38-36/37/38

Safety Statements 

36/37-36/37/39-26-36

RIDADR 

2811

WGK Germany 

3

F 

8

Hazard Note 

Irritant

TSCA 

T

HazardClass 

6.1(b)

PackingGroup 

III

HS Code 

29214210

MSDS

• Language:English Provider:2-Iodoaniline
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2-Iodoaniline Usage And Synthesis

Chemical Properties

YELLOW TO BROWN CRYSTALLINE NEEDLES

Uses

2-Iodoaniline is used as an intermediate in organic synthesis.

Uses

2-Iodobenzenamine is an synthetic intermediate for the synthesis of complex organic compounds and pharmaceuticals.

Preparation

2-iodoaniline and its derivatives are commonly used for the preparation of indole-based anticancer drugs, which have high market value, and further synthesis can lead to high-end synthetic intermediates with complex structures.
Take a reaction tube, add 50mg of sodium azide, 75mg of 1-(2-iodophenyl)ethanol, 300uL of trifluoroacetic acid, 150uL of methanesulfonic acid and 1.0mL of hexane, and stir for 24 hours at 40℃. After the reaction, 10 mL of sodium hydroxide solution was added to quench the reaction. The organic phase was washed with 5 mL of brine, and the organic phase was combined and separated by column chromatography to obtain 58.4 mg of 2-iodoaniline in 89% yield.

Synthesis of 2-iodoaniline

Purification Methods

Distil 2-iodoaniline with steam and crystallise it from *benzene/pet ether. The N-acetyl derivative has m 110o. [Beilstein 12 IV 1542.]

2-Iodoaniline(615-43-0)Related Product Information

• 6-Aminocaproic acid
• Benzidine
• Glycine
• 3-Chloroaniline
• Aniline
• o-Toluidine
• Iodobenzene
• Diphenylamine
• 4-Chloroaniline
• ALTRENOGEST
• N,N-Dimethylaniline
• EMERALDINE BASE POLYANILINE
• 3-Aminophenol
• 3-Diethylaminophenol
• m-Toluidine
• Tris(hydroxymethyl)aminomethane
• 2-BENZOYLACETANILIDE
• 4-Nitroaniline