DPQ Chemical Properties

Melting point:

107-109°

Boiling point:

528.8±50.0 °C(Predicted)

Density 

1.096±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: Soluble

form 

solid

pka

14.54±0.20(Predicted)

color 

White to off-white

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

DPQ Usage And Synthesis

Description

The poly(ADP-ribose) polymerases (PARPs) form a family of enzymes with roles in DNA repair and apoptosis, particularly in response to reactive oxygen and nitrogen species. DPQ is a potent inhibitor of PARPs, inhibiting PARP1 with an IC₅₀ value of 40 nM. It is approximately 10-fold less potent against PARP2. DPQ can be used in either cells or in animals.

Uses

DPQ has been used as a PARP1 (poly(ADP-ribose) polymerase 1) inhibitor in in vivo studies to determine the loss of γ-H2AX (H2A histone family member X) upon irradiation.

Uses

3,4-Dihydro-5-[4-(1-piperidinyl)butoxy]-1(2H)-isoquinolinone is a potent inhibitor of poly(ADP-ribose) polymerases, a family of enzymes that plays a crucial role in DNA repair and apoptosis in respons e to reactive oxygen and nitrogen species.

Uses

Reagent for inhibition of PARP.

Biochem/physiol Actions

3,4-Dihydro-5-[4-(1-piperidinyl)butoxyl]-1(2H)-isoquinolinone (DPQ) is known to decrease the PARP 1 (poly(ADP-ribose) polymerase 1) mediated apoptosis under the influence of ischemia. It is considered as more effective inhibitor than the traditionally used PARP1 inhibitor 3-aminobenzamide.

storage

+4°C

DPQ(129075-73-6)Related Product Information

• 4-AMINO-1,8-NAPHTHALIMIDE
• 3-Aminobenzamide
• NU1025
• DMEM/F12 medium
• DMEM medium
• 4-Hydroxyquinazoline
• Rucaparib
• ABT-888
• 1,5-ISOQUINOLINEDIOL
• 1(2H)-Isoquinolinone, 5-aMino-, Monohydrochloride
• 5-Benzoyloxy-1(2H)-isoquinolinone
• 3-(4-CHLORO-PHENYL)-QUINOXALINE-5-CARBOXYLIC ACID AMIDE
• TIQ-A
• 5-METHOXY-3,4-DIHYDRO-1(2H)-ISOQUINOLINONE
• DPQ
• 5-HYDROXY-3,4-DIHYDRO-2H-ISOQUINOLIN-1-ONE
• 1,2,3,4-TETRAHYDRO-ISOQUINOLIN-5-OL
• DULBECCO'S MODIFIED EAGLE'S MEDIUM W/L-&