TIQ-A Chemical Properties

Melting point:

256-258°C

Boiling point:

282.2±9.0 °C(Predicted)

Density 

1.358±0.06 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

DMSO: 16 mg/mL, soluble

form 

solid

pka

13.04±0.20(Predicted)

color 

Light green to green

Safety Information

Hazard Codes 

Xn

Risk Statements 

20/21/22

WGK Germany 

3

TIQ-A Usage And Synthesis

Chemical Properties

Dark Brown Solid

Uses

A cell permeable, potent PARP inhibitor with an IC50 of 450nM. Shown to be neuroprotective against oxygen-glucose deprivation injury in vitro in cultured murine cortical cells ( IC50 of 150nM) and in vivi in rat transient focal ischemia model (3 mg/kg ip).

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