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NU1025

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NU1025 Basic information

Product Name:
NU1025
Synonyms:
  • NU1025
  • PARP Inhibitor VI, NU1025 - CAS 90417-38-2 - Calbiochem
  • NU 1025;NU 1025
  • 8-HYDROXY-2-METHYL-4(3H)-QUINAZOLINONE
  • 8-HYDROXY-2-METHYLQUINAZOLIN-4[3H]-ONE
  • 8-HYDROXY-2-METHYLQUINAZOLINE-4-ONE
  • 8-Hydroxy-2-methylquinazoline-4-one ,97%
  • 8-hydroxy-2-methyl-1H-quinazolin-4-one
CAS:
90417-38-2
MF:
C9H8N2O2
MW:
176.17
Product Categories:
  • All Inhibitors
  • Inhibitors
  • Aromatics
Mol File:
90417-38-2.mol
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NU1025 Chemical Properties

Melting point:
253-258°C
Density 
1.42
storage temp. 
−20°C
solubility 
DMSO: 35 mg/mL, soluble
form 
solid
color 
off-white
CAS DataBase Reference
90417-38-2
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Safety Information

Hazard Codes 
Xn
Risk Statements 
22
Safety Statements 
26
WGK Germany 
3
HS Code 
29335990

MSDS

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NU1025 Usage And Synthesis

Description

NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.

Chemical Properties

Off-White to Pale Yellow Solid

Uses

NU 1025 is an inhibitor of poly(ADP-ribose) polymerases (PARP) (IC50 = 400 nM). It enhances the cytotoxicity of γ-irradiation and certain anticancer drugs. NU 1025 is also used to study the regulation of deoxyribonucleic acid repair by PARP enzymes.[Cayman Chemical]

Uses

A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively

Uses

A potent inhibitor of poly (ADP-ribose) polymerase (PARP). Ki and IC50 values are 48 and 400 nM respectively.

Definition

ChEBI: A member of the class of quinazolines that is quinazolin-4(1H)-one substituted by a hydroxy group at position 8 and a methyl group at position 2. It has been shown to exhibit inhibitory activity against poly(ADP-ribose) polymerase.

Biological Activity

Novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP). K i and IC 50 values are 48 and 400 nM respectively.

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