2-Phenoxyethylbromide Chemical Properties

Melting point:

31-34 °C(lit.)

Boiling point:

144 °C40 mm Hg(lit.)

Density 

1.45

refractive index 

1.555-1.557

Flash point:

150 °F

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

Solubility in methanol is almost transparent. Soluble in chloroform and ethyl acetate.

form 

Liquid After Melting

color 

Clear colorless

Water Solubility 

Insoluble in water.

BRN 

508290

CAS DataBase Reference

589-10-6(CAS DataBase Reference)

NIST Chemistry Reference

Benzene, (2-bromoethoxy)-(589-10-6)

EPA Substance Registry System

Benzene, (2-bromoethoxy)- (589-10-6)

Safety Information

Hazard Codes 

Xi,Xn

Risk Statements 

36/37/38-22

Safety Statements 

23-24/25-26

RIDADR 

1325

WGK Germany 

3

Hazard Note 

Irritant

TSCA 

Yes

HazardClass 

4.1

PackingGroup 

II

HS Code 

29093038

MSDS

• Language:English Provider:beta-Bromophenetole
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Phenoxyethylbromide Usage And Synthesis

Chemical Properties

White Solid

Uses

2-Phenoxyethyl bromide is used in the synthesis and antihypertensive activity of 4'-substituted spiro[4H-3,1-benzoxazine-4,4'-piperidin]-2(1H)-ones.

Application

2-Phenoxyethyl bromide can be used as a pharmaceutical intermediate for the synthesis of nafazodone and oxiperomide.

Preparation

2-Phenoxyethyl bromide is synthesized by the reaction of phenol and dibromoethane. Put phenol, dibromoethane and sodium hydroxide in a reaction pot and stir and mix, react at 110 °C for 6 hours, recover dibromoethane, the recovery amount is about 60%, wash with 5% sodium hydroxide solution and water, and divide Take the oil layer, distill under reduced pressure, and collect the fractions at 130-150°C (6.7kPa) to obtain (2-bromoethoxy)benzene.

2-Phenoxyethylbromide(589-10-6)Related Product Information

• Ethopabate
• Dimethyl ether
• Phenoxyacetic acid
• Phenoxybenzamine hydrochloride
• Ethyl 2-(4-phenoxyphenoxy)ethylcarbamate
• Tetrabromobisphenol A bis(dibromopropyl ether)
• 1-Bromo-2-methoxyethane
• Ethylbenzene
• PETROLEUM ETHER
• 2-Butoxyethanol
• Decabromodiphenyl oxide
• Allyl phenoxyacetate
• 2-Phenoxyethanol
• Glycidyl phenyl ether
• Tamoxifen
• Triton X-100
• PHENYL VALERATE
• 2-(2-Bromoethoxy)anisole