Basic information Safety Supplier Related

roemerine

Basic information Safety Supplier Related

roemerine Basic information

Product Name:
roemerine
Synonyms:
  • roemerine
  • (-)-N-Methylanonaine
  • (-)-Roemerine【alkaloid】
  • (6aR)-6-Methyl-1,2-(methylenedioxy)-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinoline
  • [7aR,(-)]-6,7,7a,8-Tetrahydro-7-methyl-5H-benzo[g]-1,3-benzodioxolo[6,5,4-de]quinoline
  • Remerine【alkaloid】
  • Roemerine【alkaloid】
  • (-)-Remerine
CAS:
548-08-3
MF:
C18H17NO2
MW:
279.33
Mol File:
548-08-3.mol
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roemerine Chemical Properties

Melting point:
102-103℃
Boiling point:
424.0±34.0 °C(Predicted)
Density 
1.269±0.06 g/cm3 (20 ºC 760 Torr)
solubility 
Chloroform: soluble
form 
A solid
pka
7.87±0.20(Predicted)
color 
White to off-white
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roemerine Usage And Synthesis

Uses

Roemerine is an (-)-aporphine type of alkaloid which has been shown to possess significant antibacterial activity against Escheria Coli.

Definition

ChEBI: Remerin is an isoquinoline alkaloid.

in vivo

Roemerine (30 mg/kg, i.p., once every three days for 30 days) significantly inhibited tumor growth in the prostate cancer BALB/C nude mouse model (established by subcutaneous implantation of RM-1 cells)[2]. Roemerine (20 mg/kg, i.p., once daily for 2 days) increases survival and reduced bacterial loads in multiple organs in the MRSA XJ75302-induced sepsis BALB/C mouse model[5].

Animal Model:Prostate cancer BALB/C nude mouse model (established by subcutaneous implantation of RM-1 cells)[3]
Dosage:30 mg/kg
Administration:Intraperitoneal injection (i.p.), once every three days for 30 days
Result:Significantly reduced tumor volume and weight in the experimental group (P < 0.05), with an inhibition rate of 41.2%.
Animal Model:MRSA XJ75302-induced sepsis BALB/C mouse model[5]
Dosage:20 mg/kg
Administration:Intraperitoneal injection (i.p.), once daily, for 2 days
Result:Increased the 7-day survival rate of mice to 58.3% (p < 0.05) and reduced bacterial loads in the liver (4.71 to 4.38 log CFU/mL), kidney (4.37 to 3.79 log CFU/mL), heart (5.44 to 3.76 log CFU/mL), and blood (6.52 to 4.55 log CFU/mL). Note: CFU/mL represents the number of bacteria per milliliter of culture medium or tissue sample that can form colonies (CFU, Colony-Forming Units).

roemerineSupplier

Wuxi Zhongkun Biochemical Technology Co., Ltd.
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0510-85629785 18013409632
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sales@reading-chemicals.com
Wuhan ChemFaces Biochemical Co., Ltd.
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18607101326 15172504745
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aileen@chemfaces.com
EMMX Biotechnology LLC
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888-539-0666
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info@emmx.com
Shanghai YuanYe Biotechnology Co., Ltd.
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021-61312847; 18021002903
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3008007409@qq.com
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
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roemerine(548-08-3)Related Product Information