4-Piperidineethanol Chemical Properties

Melting point:

46-47 °C (lit.)

Boiling point:

131-136 °C/17 mmHg (lit.)

Density 

1.0059

refractive index 

n20/D 1.4902(lit.)

Flash point:

>230 °F

storage temp. 

2-8°C

solubility 

Chloroform (Slightly), Methanol (Slightly)

form 

Oil

pka

15.10±0.10(Predicted)

color 

Brown

InChI

InChI=1S/C7H15NO/c9-6-3-7-1-4-8-5-2-7/h7-9H,1-6H2

InChIKey

LDSQQXKSEFZAPE-UHFFFAOYSA-N

SMILES

N1CCC(CCO)CC1

CAS DataBase Reference

622-26-4(CAS DataBase Reference)

NIST Chemistry Reference

4-Ethanolpiperidine(622-26-4)

EPA Substance Registry System

4-Piperidineethanol (622-26-4)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-37/39-24/25

WGK Germany 

3

Hazard Note 

Irritant

HS Code 

29333990

MSDS

• Language:English Provider:4-Ethanolpiperidine
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS

4-Piperidineethanol Usage And Synthesis

Chemical Properties

white crystalline low melting solid

Uses

Reactant for synthesis of:• ;Ursolic acid derivatives1• ;Amodiaquine analogues for treatment of cerebral malaria2• ;Spiroimidazolidinone NPC1L1 inhibitors3• ;Piperazinyl glutamate pyridines as orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation4• ;Neurokinin-2 receptor antagonists5• ;Hepatitis C virus NS5B polymerase inhibitors6

Uses

4-Piperidineethanol have been used as a intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAK

Uses

4-Piperidineethanol have been used as an intermediate in the synthetic preparation of cellular-active allosteric inhibitors of FAK

Synthesis

Lithium tetrahydroaluminum (0.06 mol) was added to ice-bath cooled anhydrous tetrahydrofuran (80 mL) under nitrogen protection, followed by the slow addition of crushed 4-piperidineacetic acid (4.95 g, 0.03 mol), and the temperature of the reaction was controlled to be no more than 30 °C. The reaction mixture was stirred at 25 °C overnight. Upon completion of the reaction, the system was cooled to 0 °C and water (3 mL), 30% aqueous sodium hydroxide solution (3 mL), and water (3 mL) were added sequentially and slowly dropwise. The resulting mixture was continued to be stirred at 25 °C for 30 min. Finally, the solvent was removed by distillation under reduced pressure to give 2.23 g of light yellow solid product in 62.5% yield.

References

[1] Patent: CN103755686, 2016, B. Location in patent: Paragraph 0099; 0100

4-Piperidineethanol(622-26-4)Related Product Information

• 2-(METHYLSULFONYL)ETHANOL
• 2,2,6,6-Tetramethyl-4-piperidinol
• Haloperidol
• Triacetonediamine
• DROPERIDOL
• 4-Piperidinemethanol
• Diphenoxylate
• STRYCHNINE HYDROCHLORIDE
• THEBAINE
• Reserpine
• Yohimbine
• RESCINNAMINE
• 10,11-Dimethoxystrychnine
• NALORPHINE HYDROCHLORIDE
• SYROSINGOPINE
• BRUCINE SULFATE
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• PIPERIDINEETHANOL, 2-,2-PIPERIDINEETHANOL