5'-DEOXYADENOSINE
5'-DEOXYADENOSINE Basic information
- Product Name:
- 5'-DEOXYADENOSINE
- Synonyms:
-
- 5’-deoxy-adenosin
- (2R,3R,4R,5R)-2-(6-aminopurin-9-yl)-5-methyl-oxolane-3,4-diol
- 6-Amino-9-(5-deoxy-β-D-ribofuranosyl)-9H-purine
- 9-(5-Deoxy-β-D-ribofuranosyl)-9H-purine-6-amine
- 5'-DEOXYADENOSINE
- Adenosine, 5'-deoxy-
- 5′-dAdo
- 2'-Deoxycytidine Monohydrate(2'-dC ? H?O)
- CAS:
- 4754-39-6
- MF:
- C10H13N5O3
- MW:
- 251.24
- Product Categories:
-
- Biochemicals and Reagents
- Nucleoside Analogs
- Nucleosides, Nucleotides, Oligonucleotides
- Mol File:
- 4754-39-6.mol
5'-DEOXYADENOSINE Chemical Properties
- Melting point:
- 210-212 °C
- Boiling point:
- 595.0±60.0 °C(Predicted)
- Density
- 1.93±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMF: 30 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.20 mg/ml; DMSO: 15 mg/ml
- form
- A crystalline solid
- pka
- 13.29±0.70(Predicted)
- color
- White to off-white
- InChIKey
- XGYIMTFOTBMPFP-KQYNXXCUSA-N
MSDS
- Language:English Provider:SigmaAldrich
5'-DEOXYADENOSINE Usage And Synthesis
Description
5'-Deoxyadenosine is an oxidized nucleoside found in the urine of normal subjects. Oxidized nucleosides represent excellent biomarkers for determining the extent of damage in genetic material, which has long been of interest in understanding the mechanism of aging, neurodegenerative diseases, and carcinogenesis.
Uses
5′-Deoxyadenosine has been used:
- as a standard in mass spectroscopy
- as an inhibitor for screening thymidine phosphorylase activity
- as a substrate in 5′-Deoxyadenosine deaminase (DadD) assay
Definition
ChEBI: A 5'-deoxyribonucleoside compound having adenosine as the nucleobase.
Biochem/physiol Actions
5′-Deoxyadenosine is a substrate for the enzyme methylthioadenosine/S-adenosylhomocysteine (MTA/SAH) nucleosidase in microbes. 5′-Deoxyadenosine is a byproduct of cleavage of S-adenosylmethionine (SAM). High levels of 5′-Deoxyadenosine inhibits SAM dependent enzymes. It also inhibits biotin synthase (BioB) and lipoyl synthase (LipA) enzymes.
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5'-DEOXYADENOSINE(4754-39-6)Related Product Information
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- N6-BENZOYL-5'-O-(4,4'-DIMETHOXYTRITYL)-2'-DEOXYADENOSINE
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