m-PEG10-acid Chemical Properties

Boiling point:

568.3±50.0 °C(Predicted)

Density 

1.112±0.06 g/cm3(Predicted)

pka

4.28±0.10(Predicted)

form 

Oil

color 

White to off-white

m-PEG10-acid Usage And Synthesis

Uses

m-PEG10-acid is a non-cleavable 10 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. m-PEG10-acid is also a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[2].

IC 50

PEGs; Non-cleavable Linker

References

[1] John F. Donovan et al. Pegylated prodrugs of phenolic trpv1 agonists. WO2020023794A1.
[2] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. DOI:10.1016/j.ebiom.2018.09.005

m-PEG10-acid(2409969-94-2)Related Product Information

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