1-Chloroethyl chloroformate Chemical Properties

Melting point:

-65°C

Boiling point:

118-119 °C (lit.)

Density 

1.325 g/mL at 25 °C (lit.)

vapor pressure 

3.25 psi ( 20 °C)

refractive index 

n20/D 1.422(lit.)

Flash point:

105 °F

storage temp. 

2-8°C

solubility 

Miscible with most organic solvents.

form 

Liquid

color 

Clear colorless

Sensitive 

Moisture Sensitive

BRN 

1747601

Stability:

Hygroscopic, Moisture Sensitive

InChIKey

QOPVNWQGBQYBBP-UHFFFAOYSA-N

CAS DataBase Reference

50893-53-3(CAS DataBase Reference)

NIST Chemistry Reference

«ALPHA»-chloroethyl chloroformate(50893-53-3)

Safety Information

Hazard Codes 

T

Risk Statements 

10-22-23-34

Safety Statements 

26-36/37/39-45

RIDADR 

UN 2742 6.1/PG 2

WGK Germany 

3

F 

10-19-21

TSCA 

No

HazardClass 

6.1

PackingGroup 

II

HS Code 

29159000

MSDS

• Language:English Provider:1-Chloroethyl chloroformate
• Language:English Provider:SigmaAldrich
• Language:English Provider:ALFA

1-Chloroethyl chloroformate Usage And Synthesis

Chemical Properties

Clear and colorless liquid

Uses

Reagent for the selective N-dealkylation of tertiary amines in high yields.

Uses

1-Chloroethyl chloroformate was used:

• for N-demethylation reaction during determination of multiple drugs of abuse in biological fluids using capillary electrophoresis with native fluorescence and laser-induced fluorescence detection
• as catalyst in chemoselective desilylation of silyl-protected alcohols
• as reagent in N-demethylation of tertiary amines to produce drug metabolite reference material for forensic toxicological applications
• as reagent to cleave benzhydryl groups from amines

1-Chloroethyl chloroformate(50893-53-3)Related Product Information

• Benzyl chloroformate
• Benzyl benzoate
• Diisononyl phthalate
• Diethyl azodicarboxylate
• Urethane
• Triethyl orthoformate
• Dimethyl phthalate
• Diethyl phthalate
• Ethyl formate
• POLYURETHANE
• Isavuconazole Impurity 35
• Efinaconazole Impurity 13
• (2R,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide
• Ethyl chloroformate
• BIS(CHLOROMETHYL)ETHER
• b-Chloroethyl chloroformate,2-CHLOROETHYL CHLOROFORMATE
• Polyol benzoate
• Chloromethyl chloroformate