QUININE SULFATE
QUININE SULFATE Basic information
- Product Name:
- QUININE SULFATE
- Synonyms:
-
- Quinine sulfate (1:1) (salt)
- QUININE BISULFATE
- 6’-methoxy-cinchonan-9-o(8alpha,9theta)-cinchonan-9-osulfate(1:1)(salt)
- A-(6-METHOXY-4-QUINOLYL)-5-VINYL-2-QUINUCLIDINE-METHANOL SULFATE
- 6-METHOXYCINCHONINE SULFATE
- QUININE HEMISULFATE
- QUININE SULFATE
- Quinine Bisulphate
- CAS:
- 549-56-4
- MF:
- C40H50N4O8S
- MW:
- 746.91
- EINECS:
- 208-970-9
- Mol File:
- 549-56-4.mol
QUININE SULFATE Chemical Properties
- Boiling point:
- 695℃[at 101 325 Pa]
- vapor pressure
- 0Pa at 25℃
- FEMA
- 2975 | QUININE BISULFATE
- form
- Solid
- color
- White to off-white
- Odor
- odorless
- Water Solubility
- 10.8g/L at 25℃
- BCS Class
- 1
- LogP
- -2.22 at 25℃
- CAS DataBase Reference
- 549-56-4(CAS DataBase Reference)
- EPA Substance Registry System
- Quinine sulfate (1:1) (549-56-4)
QUININE SULFATE Usage And Synthesis
Chemical Properties
Basic quinine sulfate is C40H50N4O8S; the dilIyrate, C40H50N4O8S·2H20, is dull needles or rods making a light and readily compressible mass that becomes brownish on exposure to light. Slightly soluble in chloroform and ether. Should be kept well closed and protected from light.
Uses are as a protective colloid in preparation of metallic colloidal solutions, photography, dyes, intermediates, synthetic drugs, medicine (antibacterial), process engraving, laboratory reagent, gas analysis (an oxygen absorber), reducing agent, and antioxidant in lubricating oils.
Chemical Properties
Quinine bisulfate has no odor, but has a bitter taste.
Physical properties
Crystals or crystalline powder. White when fresh, but may acquire a brownish tint upon exposure to air.
Uses
Quinine Bisulfate (cas# 549-56-4) is a compound useful in organic synthesis.
Uses
Antiprotozoal (malaria).
Flammability and Explosibility
Non flammable
in vivo
Quinidine sulfate is rapidly absorbed, with peak plasma concentrations 60-90 min after an oral dose. Other salts (gluconate, polygalacturonate) are more slowly absorbed, with lower peak concentrations[2].
Quinidine sulfate is approximately 70-90 % bound to plasma proteins. It undergoes hepatic oxidative metabolism to form an N-oxide, a 3-hydroxy form, an O-demethyl form and 2'-quinidinone[2].
Quinidine sulfate inhibits metabolism of amphetamine in rats. Quinidine sulfate pretreatment results in a significant decrease in the excretion of p-hydroxyamphetamine at 24 and 48 h to 7.2 and 24.1% of the vehicle-control levels, respectively, accompanied by a significant increase in amphetamine excretion between 24 and 48 h to 542% of the control[3].
IC 50
Plasmodium
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QUININE SULFATE(549-56-4)Related Product Information
- QUINUCLIDINE
- Quinine
- Quinine sulfate dihudrate
- Quinine, sulfate (2:1) (salt) (8CI),QUININE SULFATE
- Quinine sulfate *Fluorescence Reference Standard
- QUININE SULFATE USP(CRM STANDARD)
- QUININE SULFATE, FLUORESCENCE
- QUININE SULFATE SALT
- quinine,sulfate(1:1)(salt),heptahydrat
- QUININE SULFATE
- Quinine sulfate dihydrate
- QUININE SULFATE
- Quinine hydrochloride dihydrate
- QUININE SULFATE SALT MONOHYDRATE