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SOYASAPONIN I

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SOYASAPONIN I Basic information

Product Name:
SOYASAPONIN I
Synonyms:
  • SOYASAPONIN I
  • β-D-Glucopyranosiduronic acid, (3β,4β,22β)-22,23-dihydroxyolean-12-en-3-yl O-6-deoxy-α-L-Mannopyranosyl-(1→2)-O-β-D-galactopyranosyl-(1→2)-
  • 2)-O-b-D-galactopyranosyl-(1®
  • b-D-Glucopyranosiduronic acid, (3b,4b,22b)-22,23-dihydroxyolean-12-en-3-yl O-6-deoxy-a-L-Mannopyranosyl-(1®
  • SoyasaponinⅠ(Soyasaponin Bb)
  • SCM 3B
  • SOYASAPONIN BB; SOYASAPONIN I
  • SOYASAPONIN I USP/EP/BP
CAS:
51330-27-9
MF:
C48H78O18
MW:
943.13
Product Categories:
  • chemical reagent
  • pharmaceutical intermediate
  • Miscellaneous Natural Products
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
Mol File:
51330-27-9.mol
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SOYASAPONIN I Chemical Properties

Melting point:
220-222 °C(Solv: methanol (67-56-1))
Boiling point:
1024.2±65.0 °C(Predicted)
Density 
1.41
storage temp. 
2-8°C
solubility 
ethanol: soluble1mg/mL, clear, colorless
pka
2.76±0.70(Predicted)
form 
powder
color 
White
Stability:
Hygroscopic
InChIKey
PTDAHAWQAGSZDD-IOVCITQVSA-N
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Safety Information

WGK Germany 
3
HS Code 
29389090
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SOYASAPONIN I Usage And Synthesis

Description

Soyasaponin Bb is a triterpenoid saponin that has been found in soy and has enzyme inhibitory, antimetastatic, anti-inflammatory, and neuroprotective biological activities. It selectively inhibits human recombinant and porcine kidney renin (IC50s = 30 and 30 μg/ml, respectively) over bovine trypsin, human urinary kallikrein, and rabbit angiotensin converting enzyme (ACE) when used at a concentration of 100 μg/ml. Soyasaponin Bb inhibits the mouse brain sialyltransferase ST3GAL1 (Ki = 2.1 μM) and decreases levels of α2,3-linked sialic acid on the cell surface and decreases migration of B16/F10 mouse melanoma cells in vitro when used at a concentration of 75 μM. It also dose-dependently increases viability and mRNA expression of heme oxygenase-1 (HO-1) in BRL 3A immortalized rat hepatocytes subjected to alcohol-induced oxidative stress. Soyasaponin Bb (10 mg/kg per day) increases the latency to enter the dark chamber in a passive avoidance test and the percentage of spontaneous alterations in the Y-maze test in a rat model of learning and memory impairment induced by ibotenic acid .

Uses

Soyasaponin I has been used:

  • to test its effect on migration and invasion of ovarian cancer cell lines
  • as standard for the quantification of saponins from quinoa and fenugreek samples
  • as L-15 medium supplement for Zebrafish liver cell lines

Definition

ChEBI: Soyasaponin I is a triterpenoid saponin that is composed of soyasapogenol B having an alpha-L-rhamnopyranosyl-(1->2)-beta-D-galactopyranosyl-(1->2)-beta-D-glucopyranosiduronic acid moiety attached at the 3-position via a glycosidic linkage. It has a role as a sialyltransferase inhibitor. It is a pentacyclic triterpenoid, a triterpenoid saponin, a trisaccharide derivative and a carbohydrate acid derivative. It is functionally related to a soyasapogenol B. It is a conjugate acid of a soyasaponin I(1-).

General Description

Soyasaponin I is an oleanene-type triterpenoid aglycone and is a group B soyasaponin. It is an amphiphilic molecule and is metabolized by intestinal bacteria into sugars and aglycones.

Biochem/physiol Actions

Antioxidant and anti-inflammatory saponin found in soybean. Attenuates TNBS-induced colitis in mice. The structure consists of a glycoside moiety and triterpene derivative. Sialytransferase inhibitor and renin inhibitor.

SOYASAPONIN ISupplier

Shanghai Tauto Biotech Co., Ltd. Gold
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Shanghai YuanYe Biotechnology Co., Ltd. Gold
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Chembest Research Laboratories Limited
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Chengdu Biopurify Phytochemicals Ltd.
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+86-028-82633397 18982077548
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