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Methyl 6-bromo-2-naphthoate

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Methyl 6-bromo-2-naphthoate Basic information

Product Name:
Methyl 6-bromo-2-naphthoate
Synonyms:
  • 6-Bromo-2-Naphtoic Acid Methyl Ester
  • 2-Bromo-6-naphthoic acid methylester
  • 6-BROMO-2-NAPHTHALENECARBOXYLIC ACID METHYL ESTER
  • 6-BROMO-2-NAPHTHOIC ACID METHYL ESTER
  • METHYL 6-BROMO-2-NAPHTHALENECARBOXYLATE
  • METHYL 6-BROMO-2-NAPHTHOATE
  • 2-Naphthoic acid, 6-bromo, methyl ester
  • Methyl-6-bromo-2-naphtoate
CAS:
33626-98-1
MF:
C12H9BrO2
MW:
265.1
EINECS:
608-896-0
Product Categories:
  • Naphthalene series
  • Building Blocks
  • C12 to C63
  • Carbonyl Compounds
  • Chemical Synthesis
  • Organic Building Blocks
  • Aromatic Esters
  • Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts
  • Intermediates of Adapalene
  • C12 to C63
  • Carbonyl Compounds
  • Esters
  • API
  • Others chemical reagents
  • blocks
  • Bromides
  • Carboxes
  • ADAPALENE
Mol File:
33626-98-1.mol
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Methyl 6-bromo-2-naphthoate Chemical Properties

Melting point:
123-126 °C (lit.)
Boiling point:
357.0±15.0 °C(Predicted)
Density 
1.492±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly), DMSO (Slightly)
form 
Crystalline Powder
color 
Off-white to cream or light brown
BRN 
2578943
InChIKey
JEUBRLPXJZOGPX-UHFFFAOYSA-N
CAS DataBase Reference
33626-98-1(CAS DataBase Reference)
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Safety Information

Hazard Codes 
C
Risk Statements 
20/21/22-34
Safety Statements 
24/25-45-36/37/39-27-26
WGK Germany 
3
HS Code 
29163990

MSDS

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Methyl 6-bromo-2-naphthoate Usage And Synthesis

Chemical Properties

Pale yellow or light brown powder

Uses

Methyl 6-Bromo-2-napthoate (Adapalene USP Related Compound A) is used in the synthesis of Adapalene, a retinoid specific for RARβ and RARγ receptors.

Uses

Methyl 6-bromo-2-naphthoate may be used to synthesize:

  • 6-vinyl-2-naphthalencarbaldehyde
  • methyl 6-(3-tert-butyl-4-methoxyphenyl)-2-naphthoate
  • methyl 6-[3-tert-butyl-4-[(tert-butyldiethylsilyl)oxy]-phenyl]-2-naphthoate
  • methyl 6-[3-(1-adamantyl)-4-[(tert-butyldimethylsilyl)-oxy]phenyl]-2-naphthoate
  • methyl 6-[3-(1-adamantyl)-4-[[(2,3-dimethyl-1,3-dioxolan-4-yl)methylloxy]phenyl]-2-naphthoate
  • 2-bromo-6-(bromomethyl)naphthalene

Uses

Methyl 6-Bromo-2-napthoate is used in the synthesis of Adapalene, a retinoid specific for RARβ and RARγ receptors.

General Description

Methyl 6-bromo-2-naphthoate undergoes aromatic Finkelstein reaction followed by hydrolysis to afford 6-iodo-2-naphthoic acid.

Methyl 6-bromo-2-naphthoateSupplier

Shandong Xingshun New Material Co., Ltd. Gold
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J & K SCIENTIFIC LTD.
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