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D-Ephedrine hydrochloride

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D-Ephedrine hydrochloride Basic information

Product Name:
D-Ephedrine hydrochloride
Synonyms:
  • 2-MethylaMino-1-phenylpropan-2-ol
  • D-(+)-EPHEDRINE HYDROCHLORIDE
  • d-alpha-(1-methylaminoethyl)benzyl alcohol
  • D-ALPHA-(1-METHYLAMINOETHYL)BENZYL ALCOHOL HYDROCHLORIDE
  • alpha-(1-(methylamino)ethyl)-,hydrochloride,(s-(r*,s*))-benzenemethano
  • alpha-[1-(methylamino)ethyl]-,hydrochloride,[s-(theta,s)]-benzenemethano
  • (1S,2R)-(+)-EPHEDRINE HYDROCHLORIDE
  • (1S,2R)-(+)-ALPHA-(1-METHYLAMINOETHYL)BENZYL ALCOHOL HYDROCHLORIDE
CAS:
24221-86-1
MF:
C10H16ClNO
MW:
201.69
EINECS:
246-090-7
Product Categories:
  • Amines
  • Aromatics
  • Pharmaceutical Raw Materials
  • Chiral Reagents
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
Mol File:
24221-86-1.mol
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D-Ephedrine hydrochloride Chemical Properties

Melting point:
218-220 °C(lit.)
alpha 
34.3 º (c=5, H2O)
Flash point:
9℃
storage temp. 
Refrigerator
solubility 
DMF: 10 mg/ml; DMSO: 3 mg/ml; Ethanol: 10 mg/ml; PBS (pH 7.2): 5 mg/ml
form 
A crystalline solid
optical activity
[α]23/D +34.3°, c = 5 in H2O
BRN 
6118541
CAS DataBase Reference
24221-86-1(CAS DataBase Reference)
EPA Substance Registry System
Benzenemethanol, .alpha.-[(1R)-1-(methylamino)ethyl]-, hydrochloride, (.alpha.S)- (24221-86-1)
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Safety Information

Hazard Codes 
Xn,T,F
Risk Statements 
22-39/23/24/25-23/24/25-11
Safety Statements 
22-25-45-36/37-16-7
RIDADR 
UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany 
3
RTECS 
KB1925000
HS Code 
29394100

MSDS

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D-Ephedrine hydrochloride Usage And Synthesis

Chemical Properties

white crystalline powder

Uses

α- and β-Adrenergic agonist. Bronchodilator.

Safety Profile

A poison by intraperitoneal, subcutaneous, and intravenous routes. When heated to decomposition it emits very toxic fumes of HCl and NOx. See also EPHEDRINE

Purification Methods

Recrystallise the hydrochloride from EtOH/Et2O. The free base crystallises from *C6H6 with m 40-41o (Skita et al. Chem Ber 66 974 1933]. [Beilstein 13 H 254, 13 II 375, 13 III 1721, 13 IV 1879.]

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