Fmoc-D-Arg(Pbf)-OH Chemical Properties

Density 

1.37±0.1 g/cm3(Predicted)

storage temp. 

2-8°C

solubility 

Soluble in water or 1% acetic acid

form 

powder to crystal

pka

3.83±0.21(Predicted)

color 

White to Almost white

optical activity

5.2488° (C=1.0031 g/100ml, DMF)

BRN 

9537282

Major Application

peptide synthesis

InChIKey

HNICLNKVURBTKV-MUUNZHRXSA-N

SMILES

C(O)(=O)[C@@H](CCCNC=NNS(C1=C(C)C(C)=C2OC(C)(C)CC2=C1C)(=O)=O)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O

CAS DataBase Reference

187618-60-6(CAS DataBase Reference)

Safety Information

Safety Statements 

24/25

WGK Germany 

3

F 

10

HazardClass 

IRRITANT

HS Code 

29350090

Storage Class

11 - Combustible Solids

MSDS

• Language:English Provider:SigmaAldrich

Fmoc-D-Arg(Pbf)-OH Usage And Synthesis

Chemical Properties

White powder

Uses

peptide synthesis

reaction suitability

reaction type: Fmoc solid-phase peptide synthesis

Synthesis

a6.Add H-Arg(Pbf)-OH, water 120L, THF in the reactor, adjust PH=8.5 with Na2CO3.

b6.Gradually add Fmoc-Osu (Fmoc-carbosulfinylsuccinimide), control the temperature 15-20 ??, PH=8-9 in order to complete the reaction of Arg(Pbf), and try to avoid the excess of Fmoc-Osu. Osu excess.

TLC plate tracking of the reaction, starting from the addition of Fmoc-Osu, reaction time 6 hours.

c6. Purification: extraction with petroleum ether/ethyl acetate (2:1); the aqueous phase was acidified with HCl to pH = 3 and stirred for 2 hours. Acidification temperature 0-10 ??; add ethyl acetate to extract the product; wash with saturated brine to pH 6; anhydrous sodium sulfate drying, vacuum filtration to remove solids, filtrate concentration, concentrated under reduced pressure to get the solid, vacuum drying to get the product.

The purity of the product was 99.6%, the maximum single heterogeneity was 0.09%, and the L-type isomer was 0.15%.

Fmoc-D-Arg(Pbf)-OH(187618-60-6)Related Product Information

• L-Arginine hydrochloride
• Fmoc-N'-methyltrityl-L-lysine
• Argipressine
• 9-Fluorenylmethyl chloroformate
• Fmoc-8-amino-3,6-dioxaoctanoic acid
• L(+)-Arginine
• Sulfuryl chloride
• ARGINASE
• Fmoc-OSu
• FMOC-THR(TBU)-OL
• FMOC-ASU-OH
• Fmoc
• N-Fmoc-N'-(4-methoxy-2,3,6-trimethylbenzenesulfonyl)-D-arginine
• Fluorine
• arginine aspirin
• N5-[[[(2,3-Dihydro-2,2,4,6,7-pentamethyl-5-benzofuranyl)sulfonyl]amino]iminomethyl]-D-ornithine
• FMOC-D-ARG(PBF)-OPFP
• 2,2,4,6,7-PENTAMETHYLDIHYDROBENZOFURAN-5-SULFONAMIDE