4-Hydroxy-6-(trifluoromethyl)pyrimidine Chemical Properties

Melting point:

169-171 °C(lit.)

Boiling point:

130.3±50.0 °C(Predicted)

Density 

1.55±0.1 g/cm3(Predicted)

storage temp. 

Sealed in dry,Room Temperature

pka

6.41±0.40(Predicted)

form 

Crystalline

color 

White

Water Solubility 

Solubility in methanol (almost transparency). Slightly soluble in water.

BRN 

145548

CAS DataBase Reference

1546-78-7(CAS DataBase Reference)

Safety Information

Hazard Codes 

Xi

Risk Statements 

36/37/38

Safety Statements 

26-36

WGK Germany 

3

HazardClass 

IRRITANT

HS Code 

29335990

MSDS

• Language:English Provider:SigmaAldrich

4-Hydroxy-6-(trifluoromethyl)pyrimidine Usage And Synthesis

Chemical Properties

White powder

Uses

4-Hydroxy-6-(trifluoromethyl)pyrimidine (6-(Trifluoromethyl)-4-pyrimidinol) may be used in the synthesis of 10-[3-(6-trifluoromethyl-pyrimidin-4-yloxy)-propoxy]-(20S)-camptothecin.

Uses

4-Hydroxy-6-(trifluoromethyl)pyrimidine is used as building block in chemical synthesis. Attributes Development Product Contact

Synthesis Reference(s)

Journal of the American Chemical Society, 80, p. 5744, 1958 DOI: 10.1021/ja01554a041

General Description

4-Hydroxy-6-(trifluoromethyl)pyrimidine, a pyrimidine derivative, is a heterocyclic building block.

Synthesis

Ethyl trifluoroacetoacetate (0.16 mL, 1.0 eq.) and DBU (0.19 mL, 1.2 eq.) were added to a three-necked flask, followed by the addition of anhydrous ethanol (10 mL) to dissolve the reactants. An ethanol solution of formamidine hydrochloride (0.09 g formamidine hydrochloride dissolved in 2 mL of ethanol, 1.05 equiv. of formamidine hydrochloride) was prepared and added to the reaction system. The reaction temperature was adjusted to 70-80 °C and maintained for 3-5 hours, during which the progress of the reaction was monitored by TLC. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was diluted with water (20 mL) and the pH was adjusted to 6-7 with 1 mol/L hydrochloric acid.Subsequently, the aqueous phase was extracted with ethyl acetate (3 × 8 mL), the organic phases were combined and dried with anhydrous sodium sulfate. After filtration, the solvent was removed by vacuum distillation to give a light yellow solid. The solid was washed with petroleum ether (5 mL), filtered and the filter cake was washed with petroleum ether. Finally, the product was dried in an oven at 55 °C for 2 h to give a light yellow flaky solid in 96% yield.

References

[1] Patent: CN106188013, 2016, A. Location in patent: Paragraph 0012; 0013; 0019

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