DECURSINOL ANGELATE Chemical Properties

Melting point:

93-94 °C

Boiling point:

469.4±45.0 °C(Predicted)

Density 

1.24±0.1 g/cm3(Predicted)

storage temp. 

4°C, protect from light

solubility 

DMF: 10 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 2 mg/ml; Ethanol: 1 mg/ml

form 

A crystalline solid

color 

White to off-white

DECURSINOL ANGELATE Usage And Synthesis

Uses

Decursinol angelate, a cytotoxic and protein kinase C (PKC) activating agent from the root of Angelica gigas, possesses anti-tumor and anti-inflammatory activities[1][2].

Biological Activity

Decursinol Angelate is a pyranocoumarin isolated from medical plant Angelica gigas th at exhibits potent anti-inflammatory properties. Decursinol Angelate appears to suppress type 17 helper T (Th17) cell responses in dextran sodium sulfate-induced colitis model. Decursinol Angelate reduces the production of NF-KB and COX-2 induced proinflammatory cytokine levels on TPA induced mice ear edema.

References

[1] Ahn KS, et al. Decursinol angelate: a cytotoxic and protein kinase C activating agent from the root of Angelica gigas. Planta Med. 1997 Aug;63(4):360-1. DOI:10.1055/s-2006-957701
[2] Lee S, et al. Anti-tumor activities of decursinol angelate and decursin from Angelica gigas. Arch Pharm Res. 2003 Sep;26(9):727-30. DOI:10.1007/BF02976682

DECURSINOL ANGELATE(130848-06-5)Related Product Information

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