Neferine
Neferine Basic information
- Product Name:
- Neferine
- Synonyms:
-
- Phenol,4-[[(1S)-1,2,3,4-tetrahydro-6,7-diMethoxy-2-Methyl-1-isoquinolinyl]Methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-Methoxy-1-[(4-Methoxyphenyl)Methyl]-2-Methyl-7-isoquinolinyl]oxy]-
- 4-[[(1S)-1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methyl-1-isoquinolinyl]methyl]-2-[[(1R)-1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methyl-7-isoquinolinyl]oxy]-phenol
- 4-[(1,2,3,4-Tetrahydro-6,7-dimethoxy-2-methylisoquinolin-1-yl)methyl]-2-[[1,2,3,4-tetrahydro-6-methoxy-1-[(4-methoxyphenyl)methyl]-2-methylisoquinolin-7-yl]oxy]phenol
- 4-[[(1R)-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-1-yl]methyl]-2-[[(1R)-6-methoxy-1-(4-methoxybenzyl)-2-methyl-3,4-dihydro-1H-isoquinolin-7-yl]oxy]phenol
- Neferin
- NEFERINE
- 4''-O-Methylliensinine
- Methylliensinine
- CAS:
- 2292-16-2
- MF:
- C38H44N2O6
- MW:
- 624.77
- Product Categories:
-
- reference standards from Chinese medicinal herbs (TCM).
- standardized herbal extract
- chemical reagent
- pharmaceutical intermediate
- phytochemical
- Mol File:
- 2292-16-2.mol
Neferine Chemical Properties
- Melting point:
- 59-61 °C
- Boiling point:
- 710.9±60.0 °C(Predicted)
- Density
- 1.185±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- DMSO: >15mg/mL
- form
- powder
- pka
- 9.28±0.45(Predicted)
- color
- white to beige
- optical activity
- [α]/D -34 to -44° (c=0 3. CHCl3)
- InChIKey
- MIBATSHDJRIUJK-ROJLCIKYSA-N
Neferine Usage And Synthesis
Description
A bisbenzylisoquinoline alkaloid from Nelumbo nucifera, the structure of this base has been shown to be that represented above based upon chemical degrada_x0002_tive studies and spectroscopic data. Four methoxyl groups, one hydroxyl and two methylimino groups are present.
Uses
Neferine is an isoquinoline alkaloid which enhances the antitumor effect of Mitomycin-C in hela cells through activation of p38-MAPK. Useful in the treatment of cervical cancers.
Definition
ChEBI: Neferine is a member of isoquinolines.
Biochem/physiol Actions
Neferine is a bis-benzylisoquinoline alkaloid isolated from the green seed embryos Nelumbo Nucifera Gaertn (Lotus) that displays multiple pharmacological activities including anti-tumor, antidepressant-like and antiarrhythmic actions. Recent studies shown that neferine potently inhibits proliferation of human osteosarcoma cells while is low-toxic on non-neoplastic human osteoblast cells. Apparently in U2OS cells, neferine stabilizes p21 through the activation of p38 MAPK, which leads to G1 cell cycle arrest. Also, neferine inhibits Ang II-induced HUVSMC proliferation by upregulation of HO-1.
References
Yang, Chen.,J. Chin. Chem. Soc., 17,235 (1970)
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