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L-4-Fluorophenylalanine

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L-4-Fluorophenylalanine Basic information

Product Name:
L-4-Fluorophenylalanine
Synonyms:
  • (S)-2-AMINO-3-(4-FLUORO-PHENYL)-PROPIONIC ACID
  • RARECHEM BK PT 0031
  • P-FLUORO-L-PHENYLALANINE
  • P-FLUORO-PHENYLALANINE
  • L-4-FLUOROPHE
  • L-4-FLUOROPHENYLALANINE
  • H-L-PHE(4-F)-OH
  • H-PHE(4-F)-OH
CAS:
1132-68-9
MF:
C9H10FNO2
MW:
183.18
EINECS:
145-896-5
Product Categories:
  • Phenylalanine analogs and other aromatic alpha amino acids
  • Phenylalanine [Phe, F]
  • Unusual Amino Acids
  • Amino hydrochloride
  • a-amino
  • Non-natural amino acids
  • Amino Acids
Mol File:
1132-68-9.mol
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L-4-Fluorophenylalanine Chemical Properties

Melting point:
~255 °C (dec.)
alpha 
-26.5 º (c=1, H2O 25 ºC)
Boiling point:
313.3±32.0 °C(Predicted)
Density 
1.1939 (estimate)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
solubility 
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
pka
2.20±0.10(Predicted)
form 
powder to crystal
color 
White to Almost white
Water Solubility 
Soluble in water and 0.5M HCl (50 mg/ml).
BRN 
2416148
CAS DataBase Reference
1132-68-9(CAS DataBase Reference)
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Safety Information

Safety Statements 
23-24/25
WGK Germany 
3
RTECS 
DW1765000
Hazard Note 
Harmful
HS Code 
29224999

MSDS

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L-4-Fluorophenylalanine Usage And Synthesis

Chemical Properties

white to off-white powder

Uses

4-Fluoro-L-phenylalanine is a substrate for tyrosine hydroxylase (TH) that has been used to study the regulation of that enzyme.

Definition

ChEBI: A L-phenylalanine derivative that is L-phenylalanine in which the hydrogen at position 4 on the benzene ring is replaced by a fluoro group.

Purification Methods

It is recrystallised from aqueous EtOH. The (R)-N-acetyl derivative has m 142-145o, [] D -38.6o (c 8, EtOH). [Bennett & Nieman J Am Chem Soc 72 1800 1950, Beilstein 14 III 1268.]

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