TERT-BUTYL-2-CHLORO-2-TRIMETHYLSILYLACETATE
TERT-BUTYL-2-CHLORO-2-TRIMETHYLSILYLACETATE Basic information
- Product Name:
- TERT-BUTYL-2-CHLORO-2-TRIMETHYLSILYLACETATE
- Synonyms:
-
- TERT-BUTYL-2-CHLORO-2-TRIMETHYLSILYLACETATE
- tert-Butyl-2-chloro-2-trimethylsilylacetate**CUSTOMSYNTHESISPLEASEASK**
- t-Butyl 2-Chloro-2-trimethylsilylacetate
- REVBFXGFKCMPSR-UHFFFAOYSA-N
- Acetic acid, 2-chloro-2-(trimethylsilyl)-, 1,1-dimethylethyl ester
- CAS:
- 66406-43-7
- MF:
- C9H19ClO2Si
- MW:
- 222.78
- Mol File:
- 66406-43-7.mol
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TERT-BUTYL-2-CHLORO-2-TRIMETHYLSILYLACETATE Chemical Properties
- Boiling point:
- 221.2±20.0 °C(Predicted)
- Density
- 0.976±0.06 g/cm3(Predicted)
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TERT-BUTYL-2-CHLORO-2-TRIMETHYLSILYLACETATE Usage And Synthesis
Application
Tert-butyl-2-chloro-2-trimethylsilylacetate can olefinate enolizable ketones via the Peterson enolation reaction to generate functionalized tetrasubstituted olefins (α,β-unsaturated esters).
Preparation
Tert-butyl-2-chloro-2-trimethylsilylacetate is prepared from t-Butyl Chloroacetate by sequential reaction with Lithium Diisopropylamide and Chlorotrimethylsilane followed by aqueous workup and distillation.
storage
As this material is an activated alkyl halide, it must be considered a potential alkylating agent and lachrymator and handled with care and suitable protective clothing (e.g. gloves) in a fume hood.