METHYL (TRIMETHYLSILYL)ACETATE
METHYL (TRIMETHYLSILYL)ACETATE Basic information
- Product Name:
- METHYL (TRIMETHYLSILYL)ACETATE
- Synonyms:
-
- METHYLTRIMETHYLSILICATE
- METHYL (TRIMETHYLSILYL)ACETATE
- Methyl 2-(triMethylsilyl)acetate
- 2-(Trimethylsilyl)acetic acid methyl ester
- 2-[Dimethyl(methyl)silyl]acetic acid methyl ester
- Trimethylsilylacetic acid methyl ester
- Methyl (trimethylsilyl)acetate,98%
- Acetic acid, 2-(trimethylsilyl)-, methyl ester
- CAS:
- 2916-76-9
- MF:
- C6H14O2Si
- MW:
- 146.26
- EINECS:
- 220-845-0
- Product Categories:
-
- C6 to C7
- Carbonyl Compounds
- Esters
- Mol File:
- 2916-76-9.mol
METHYL (TRIMETHYLSILYL)ACETATE Chemical Properties
- Boiling point:
- 38-39 °C13 mm Hg(lit.)
- Density
- 0.891 g/mL at 25 °C(lit.)
- refractive index
- n20/D 1.414(lit.)
- Flash point:
- 91 °F
- storage temp.
- Flammables area
- Specific Gravity
- 0.890
- Hydrolytic Sensitivity
- 2: reacts with aqueous acid
- BRN
- 1098961
Safety Information
- Hazard Codes
- F,Xi
- Risk Statements
- 11-36/37/38
- Safety Statements
- 16-26-36
- RIDADR
- UN 3272 3/PG 3
- WGK Germany
- 3
- F
- 10-21
- TSCA
- No
- HazardClass
- 3.1
- PackingGroup
- II
- HS Code
- 29319090
MSDS
- Language:English Provider:SigmaAldrich
- Language:English Provider:ACROS
METHYL (TRIMETHYLSILYL)ACETATE Usage And Synthesis
Chemical Properties
CLEAR COLOURLESS LIQUID
Uses
Methyl 2-(Trimethylsilyl)acetate is a useful compound in the organic synthesis.
General Description
Methyl trimethylsilylacetate on reaction with lithium diisopropylamide in THF at -78°C yields methyl lithiotrimethylsilylacetate. It also undergoes Peterson olefination to yield mainly Z-isomers of steroid 17β-side chain methyl acrylates.
Purification Methods
Methyl trimethylsilylacetate [2916-76-9] M 146.3, b 65-68o/50mm, d 4 0.89. Dissolve it in Et2O, shaken with 1M HCl, wash with H2O, aqueous saturated NaHCO3, H2O again, and dry it (a precipitate may be formed in the NaHCO3 solution and should be drawn off and discarded). The solvent is distilled off, and the residue is fractionated through a good column. IR (CHCl3) max 1728cm1 . [Fessenden & Fessenden J Org Chem 32 3535 1967, Matsuda et al. J Org Chem 45 237 1980, Beilstein 4 III 1855, 4 IV 3974 for Et ester.]
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METHYL (TRIMETHYLSILYL)ACETATE(2916-76-9)Related Product Information
- TERT-BUTYL TRIMETHYLSILYLACETATE
- (TRIMETHYLSILYL)ACETIC ACID
- Trimethylsilyl acetate
- ETHYL TRIMETHYLSILYLDIFLUOROACETATE
- TERT-BUTYL-2-CHLORO-2-TRIMETHYLSILYLACETATE
- ETHYL (DIPHENYLMETHYLSILYL)ACETATE
- 2,2-DIFLUORO-2-(TRIMETHYLSILYL)ACETIC ACID PROPYL ESTER
- METHYL 2-(TRIMETHYLSILYL)PROPIONATE
- METHYL TRIMETHYLSILYLDIFLUOROACETATE
- (S)-4-((R)-2-BENZYLOXY-TRIDECYL)-3-HEXYL-3-TRIMETHYLSILANYL-OXETAN-2-ONE
- METHYL (1-TRIMETHYLSILYL)ACRYLATE
- ETHYL 2-BROMO-2-(1,1,1-TRIMETHYLSILYL)ACETATE
- METHYL (TRIMETHYLSILYL)ACETATE
- Ethyl (trimethylsilyl)acetate