1-METHYLURIC ACID Chemical Properties

Melting point:

>325°C

Boiling point:

315.51°C (rough estimate)

Density 

1.5283 (rough estimate)

refractive index 

1.6500 (estimate)

storage temp. 

Refrigerator

solubility 

Aqueous Base (Slightly, Heated), DMSO (Slightly, Heated, Sonicated)

form 

Solid

pka

5.60±0.50(Predicted)

color 

Pale Yellow to Pale Brown

Water Solubility 

1.585g/L(temperature not stated)

BRN 

195190

Safety Information

WGK Germany 

3

HS Code 

29242990

MSDS

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1-METHYLURIC ACID Usage And Synthesis

Chemical Properties

White to Off-White Solid

Uses

1-Methyluric acid, a metabolite of Theophylline, has been used:
for the determination of uric acid in stool samples by liquid chromatography and tandem mass spectrometry
in turbidimetric assay of synthetic urine samples
as a substrate for CYP1A2(cytochrome P450 family 1 subfamily A member 2) assay

Definition

ChEBI: An oxopurine that is 7,9-dihydro-1H-purine-2,6,8(3H)-trione substituted by a methyl group at N-1. It is one of the metabolites of caffeine found in human urine.

Biochem/physiol Actions

1-Methyluric acid (1-U) is a major metabolite of caffeine and theophylline with antioxidant activity that protects molecules such as low density lipoproteins (LDL) from oxidative modifications. 1-Methyluric acid may be used in studies aimed at differentiating the activities of caffeine and theophylline metabolites.

Purification Methods

Recrystallise it from H2O. Its solubility at 17.5o is 1g in 353mL of H2O. [Bergmann & Dikstein J Am Chem Soc 77 691 1955.] It has UV: max at 231 and 283nm (pH 3), and 217.5 and 292.5nm (pH >12) [Johnson Biochem J 5 133 1952]. [Beilstein 26 II 299, 26 III/IV 2621.]

1-METHYLURIC ACID(708-79-2)Related Product Information

• p-Toluic acid
• Methylcyclohexane
• Theanine
• Chlorotrimethylsilane
• Tetramethyl uric acid
• Uric acid
• 1-METHYLURIC ACID
• 1,3,7-TRIMETHYLURIC ACID
• TETRAMETHYLURIC ACID
• 1,3-Dimethyluric acid
• 9-METHYLURIC ACID
• 1,9-DIMETHYL-2,6,8-TRIHYDROXYPURINE
• [7-CD3]-1,3,7-Trimethyluric Acid
• 1-METHYLURIC ACID-D3
• 1,7-DIMETHYLURIC ACID
• 7-METHYLURIC ACID
• 3-METHYLURIC ACID