N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)
N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture) Basic information
- Product Name:
- N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)
- Synonyms:
-
- 4-[1-[4-[2-(methylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol
- 4OHNDtam
- E/Z Endoxifen
- N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)
- 4-hydroxy-N-desmethyltamoxifen
- 4-[(E)-1-[4-(2-methylaminoethoxy)phenyl]-2-phenyl-but-1-enyl]phenol
- 4-[(Z)-1-[4-[2-(Methylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol
- N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture) see H938500
- CAS:
- 110025-28-0
- MF:
- C25H27NO2
- MW:
- 373.49
- Product Categories:
-
- Aromatics
- Intermediates & Fine Chemicals
- Metabolites & Impurities
- Pharmaceuticals
- Mol File:
- 110025-28-0.mol
N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture) Chemical Properties
- Melting point:
- 63-72°C
- Boiling point:
- 519.3±50.0 °C(Predicted)
- Density
- 1.099±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- Chloroform, Dichloromethane, DMSO, Methanol
- form
- Solid
- pka
- 9.38±0.15(Predicted)
- color
- Light Brown to Light Purple
- InChI
- InChI=1S/C25H27NO2/c1-3-24(19-7-5-4-6-8-19)25(20-9-13-22(27)14-10-20)21-11-15-23(16-12-21)28-18-17-26-2/h4-16,26-27H,3,17-18H2,1-2H3
- InChIKey
- MHJBZVSGOZTKRH-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=C(C(C2=CC=C(OCCNC)C=C2)=C(C2=CC=CC=C2)CC)C=C1
N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture) Usage And Synthesis
Chemical Properties
Brown Foam
Uses
A novel active metabolite of the anti-cancer drug Tamoxifen. It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast ca
Uses
A novel active metabolite of the anti-cancer drug Tamoxifen (T006000). It showed potent ER binding property, blocked estrogen stimulated growth of breast cancer cell and half maximal inhibition of estrogen responsive gene expression in ER pos. human breast cancer cell line.
in vivo
Orally administered Endoxifen is rapidly absorbed and systemically available when tested in female rats. The Endoxifen-treated rats show 787% higher exposure (AUC0–∞) and 1,500% higher concentration (Cmax) levels of Endoxifen when compared with Tamoxifen. Oral Endoxifen administration once a day for 28 consecutive days at dosages 2, 4, and 8 mg/kg proves safe and results in progressive inhibition of the growth of the human mammary tumor xenografts in female mice[2].
IC 50
Aromatase; ERα
storage
Store at +4°C
N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)Supplier
- Tel
- 010-010-62452898 13581984929
- jlzhang929@163.com
- Tel
- 18210857532; 18210857532
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- 025-83697070
- info@chemlin.com.cn
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- 021-50135380
- shchemsky@sina.com
- Tel
- 16314854226
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N-Desmethyl-4-hydroxy Tamoxifen (approx. 1:1 E/Z Mixture)(110025-28-0)Related Product Information
- 4Hydroxy Tamoxifen
- Tamoxifen EP Impurity D
- (E)-4-Alloxycarboxyl Tamoxifen
- desdimethyltamoxifen
- TAMOXIFEN-N-OXIDE
- Droloxifene
- (E)-4-Acetoxy Tamoxifen
- N-Desmethyl Tamoxifen Methanethiosulfonate
- 2-[4-[(E)-1,2-diphenylbut-1-enyl]phenoxy]-N,N-dimethyl-ethanamine
- alpha-[4-[2-(dimethylamino)ethoxy]phenyl]-beta-ethyl-alpha-phenylphenethyl alcohol
- (E)-4-Hydroxy-N-desmethyl Tamoxifen
- 4-HYDROXYTAMOXIFEN
- N-Desmethyl-4-hydroxy Tamoxifen β-D-Glucuronide (E/Z Mixture)
- 1-(4-(2-Dimethylamino)-2-ethoxyphenyl butanone
- TaMoxifen DiMer
- 4-Benzyloxy β-Hydroxy TaMoxifen
- Tamoxifen Impurity 3
- Avacopan