N-Acetyl-L-glutamic acid Chemical Properties

Melting point:

194-196 °C(lit.)

alpha 

-16 º (c=1, water)

Boiling point:

324.41°C (rough estimate)

Density 

1.4119 (rough estimate)

refractive index 

-15 ° (C=1, H2O)

FEMA 

4752 | N-ACETYL GLUTAMATE

storage temp. 

2-8°C

solubility 

36g/l (Lit.)

pka

3.45±0.10(Predicted)

form 

Solid

color 

White

optical activity

[α]22/D 15.6°, c = 1 in H2O

Water Solubility 

2.7 g/100 mL (20 ºC)

BRN 

1727473

LogP

-2.131 (est)

CAS DataBase Reference

1188-37-0(CAS DataBase Reference)

NIST Chemistry Reference

N-acetyl-l-glutamic acid(1188-37-0)

EPA Substance Registry System

L-Glutamic acid, N-acetyl- (1188-37-0)

Safety Information

Safety Statements 

24/25

WGK Germany 

2

RTECS 

LZ9725000

TSCA 

Yes

HS Code 

29241900

MSDS

• Language:English Provider:N-Acetyl-L-glutamic acid
• Language:English Provider:SigmaAldrich
• Language:English Provider:ACROS
• Language:English Provider:ALFA

N-Acetyl-L-glutamic acid Usage And Synthesis

Chemical Properties

white crystalline powder

Uses

N-Acetyl-L-glutamic Acid is the N-Acetyl analogue of the non-essential amino acid, L-glutamic acid (G596960). N-Acetyl-L-glutamic Acid activates carbamoyl phosphate synthetase in the urea cycle.

Uses

Substrate for acetylglutamate kinase. Inhibitor of N-acetyl-L-glutamate synthetase

Uses

N-Acetyl-L-glutamic acid is used as pharmaceutical intermediates.

Definition

ChEBI: N-acetyl-L-glutamic acid is an N-acyl-L-amino acid that is L-glutamic acid in which one of the amine hydrogens is substituted by an acetyl group. It has a role as a Saccharomyces cerevisiae metabolite and a human metabolite. It is a N-acetyl-L-amino acid and a N-acyl-L-glutamic acid. It is functionally related to a L-glutamic acid. It is a conjugate acid of a N-acetyl-L-glutamate(1-).

Purification Methods

A likely impurity is glutamic acid. Crystallise it from boiling water. It inhibits N-acetyl-L-glutamate synthase. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 1948 1961, Shigesada & Tatibana Eur J Biochem 84 285 1978, Coude Biochem Biophys Res Commun 102 1016 1981, Beilstein 4 IV 3047.]

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