2-Amino-1,3,4-thiadiazole Chemical Properties

Melting point:

188-191 °C (dec.) (lit.)

Boiling point:

238.9±23.0 °C(Predicted)

Density 

1.385 (estimate)

refractive index 

1.5800 (estimate)

storage temp. 

Keep in dark place,Sealed in dry,Room Temperature

solubility 

water: soluble25mg/mL, clear, colorless

form 

Crystals or Crystalline Powder

pka

pKa 3.2 (Uncertain)

color 

White to light yellow

Water Solubility 

It is soluble in water, hot methanol- very faint turbidity.

BRN 

107135

InChIKey

QUKGLNCXGVWCJX-UHFFFAOYSA-N

CAS DataBase Reference

4005-51-0(CAS DataBase Reference)

NIST Chemistry Reference

2-Amino-1,3,4-thiadiazole(4005-51-0)

Safety Information

Hazard Codes 

Xn,Xi

Risk Statements 

68-63-36/37/38-20/21/22-22

Safety Statements 

36/37/39-26-36

RIDADR 

2811

WGK Germany 

3

RTECS 

XI3000000

Hazard Note 

Harmful

HazardClass 

6.1

PackingGroup 

III

HS Code 

29349990

Toxicity

LD50 oral in rat: 253mg/kg

MSDS

• Language:English Provider:1,3,4-Thiadiazol-2-amine
• Language:English Provider:ACROS
• Language:English Provider:ALFA

2-Amino-1,3,4-thiadiazole Usage And Synthesis

Chemical Properties

white to light yellow crystal powde

Uses

A thiadiazole derivative with fungacidal properties. An antitumor agent.

Uses

2-Amino-1,3,4-thiadiazole, is used as an intermediate for ceftraoline.

General Description

2-Amino-1,3,4-thiadiazole (donor) form charge transfer complexes with 2,3-dichloro-5,6-dicyano-p-benzoquinone, p-chloranil, o-chloranil, p-bromanil and chloranilic acid (acceptors). Effects of 2-amino-1,3,4-thiadiazole [aminothiadiazole (NSC 4728)] on purine and pyrimidine ribonucleotide pools of L1210 ascites cells in vivo has been reported.

Safety Profile

Poison by subcutaneous andintraperitoneal routes. An experimental teratogen. Otherexperimental reproductive effects. When heated todecomposition it emits very toxic fumes of NOx and SOx.

2-Amino-1,3,4-thiadiazole(4005-51-0)Related Product Information

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